κ-yeast toxin 1
| Potassium channel toxin kappa-KTx 1.1 | ||
|---|---|---|
| other names |
Kappa yeast toxin 1 |
|
| Mass / length primary structure | 22 amino acids , 2,660 Da | |
| Identifier | ||
| External IDs | ||
| Occurrence | ||
| Parent taxon | Heterometrus fulvipes | |
κ-yeast toxin 1 is a toxin from the scorpion Heterometrus fulvipes .
properties
Yeast butoxin is a protein and scorpion toxin from the scorpion Heterometrus fulvipes , as is κ-yeast toxin 2 . It slows down the activation of the potassium channel Kv1.3 / KCNA3 and inhibits Kv1.3 / KCNA3 and Kv1.2 / KCNA2 , but not Kv1.1 / KCNA1 . No structurally related proteins are known to the toxins κ-yeastutoxin 1 and 2.
Individual evidence
- ↑ KN Srinivasan, V. Sivaraja, I. Huys, T. Sasaki, B. Cheng, TK Kumar, K. Sato, J. Tytgat, C. Yu, BC San, S. Ranganathan, HJ Bowie, RM Kini, P. Gopalakrishnakone: kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity. In: The Journal of biological chemistry. Volume 277, Number 33, August 2002, pp. 30040-30047, doi : 10.1074 / jbc.M111258200 , PMID 12034709 .