Bone marrow cancer

As Knochenmarkkarzinose (also Knochenmarkskarzinose , Engl. Bone marrow carcinosis ) is called diffuse or kleinherdige infiltration of the bone marrow with metastasis of a cancer .

description

Bone marrow carcinosis is a complication of bone metastases that occurs in approximately 8 to 10% of all bone metastasis cases. The metastatic cancer cells penetrate the medullary spaces ( substantia spongiosa ) of the bones . This leads to a reduction or even a stop in the formation of blood-forming cells (the latter: terminal myelosuppression ). Correspondingly, bone marrow carcinosis manifests itself through symptoms such as anemia , reduced blood clotting caused by thrombocytopenia and a disturbed immune system (increased tendency to infection caused by leukopenia ). The treatment of bone marrow carcinosis is purely palliative .

diagnosis

Bone marrow cancer can be detected using a bone marrow biopsy. The cancer cells can be seen in the bone marrow smear. Sporadic erythroblasts and immature granulocytes are found in the peripheral blood . The number of reticulocytes is often slightly increased.

forecast

The prognosis for bone marrow cancer is extremely poor. The cancer is already well advanced and a cure is usually no longer possible.

further reading

• MT Kelleher, A. Kendall, S. Chowdhury: Bone marrow carcinosis and disseminated tumor cells. In: Onkologie Volume 33, Numbers 1-2, 2010, pp. 7-9, ISSN  1423-0240 . doi : 10.1159 / 000271606 . PMID 20164654 .
• V. Bjelic-Radisic, H. Stöger, R. Winter, C. Beham-Schmid, E. Petru: Long-term control of bone marrow carcinosis and severe thrombocytopenia with standard-dose chemotherapy in a breast cancer patient: a case report. In: Anticancer Research Volume 26, Number 2B, 2006 Mar-Apr, pp 1627-1630, ISSN  0250-7005 . PMID 16619583 .

Individual evidence

1. ↑ IJ Diel, H. Seegenschmiedt: treatment of Skelletmetastasen. In: H.-J. Schmoll, K. Höffken, K. Possinger (Eds.): Compendium of internal oncology.  ( Page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. (PDF; 792 kB) Springer Verlag 2006, ISBN 978-3-540-20657-6 , pp. 994-1014. limited preview in Google Book search  
2. ↑ AA Kurth, L. Hovy, T. Hennig: bisphosphonate bone diseases. Birkhäuser, 2001, ISBN 3-798-51266-3 , p. 37. Limited preview in the Google book search
3. ↑ P. Frick: Blood and bone marrow morphology. Georg Thieme Verlag, 2003, ISBN 3-134-00419-4 , p. 43. Restricted preview in the Google book search

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !