Knud crab

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Knud Haraldsen Krabbe (born March 3, 1885 in Frederiksberg , † May 8, 1961 in Copenhagen ) was a Danish neurologist . He is the first to describe the metabolic disease Krabbe's disease (globoid cell leukodystrophy).

Life

Krabbe was the son of the doctor Harald Krabbe (1831-1917) and his wife Kristin (1841-1910). The couple had three other children. He visited the metropolitan center in Copenhagen and studied medicine at the University of Copenhagen until 1909 . This was followed by study visits to London and Paris until June 1910 . In 1915 he was with the work Histologiske undersøgelser over corpus pineal (German: Histological studies of the pineal gland ) PhD . He worked as a neurologist in various hospitals and in private practice. From 1931 to 1955 he was a neurologist at Sankt Josephs Hospital in Copenhagen and from 1933 to 1955 he was also a senior physician for neurology at the Kommunehospitalet . In 1949 he was a visiting professor in Reykjavík and in 1950 in Rio de Janeiro .

Knud Krabbe was married to the lawyer Agnete Hindenburg (1883–1961) since 1909. The couple had two daughters.

Act

Krabbe's early scientific interest belonged to the pineal gland , on whose histology he also wrote his dissertation. Later he turned mainly to neuropediatric diseases. In 1916, Krabbe described five cases of a progressive, fatal disease in infants in the journal Brain , characterized by an increase in muscle tone, developmental deficits, fever attacks and opisthotonus . It was the infantile form of globoid cell leukodystrophy, a sphingolipidosis , which today is called Krabbe's disease after its first description .

Later extensive work was devoted to the morphogenesis of the vertebrate brain (Vertebrata).

Krabbe wrote a textbook on neurology that was published several times and was editor of the journal Acta psychiatrica et neurologica from 1926 to 1956, which he founded . He was a member and honorary member of numerous professional societies and honorary doctorates from Lund University (1950) and the Karolinska Institute (1951). He was also Knight of the Legion of Honor (1949) and a member of the Royal Physiographical Society in Lund .

Publications (selection)

  • Histologiske Undersøgelser over corpus pineale. J. Gjellerups, Copenhagen 1915. (Dissertation)
  • A new familial, infantile form of diffuse brain-sclerosis. In: Brain . 39, 1916, pp. 74-114, doi : 10.1093 / brain / 39.1-2.74 .
  • Forelaesninger over Nervesygdomme for medicinske Studerende og practical camps . Levin & Munksgaard, Copenhagen 1927. (7th edition 1952)
  • Studies on the morphogenesis of the brain in reptiles. Copenhagen 1939.
  • Studies on the morphogenesis of the brain in lower mammals. Copenhagen 1942.
  • Studies on the morphogenesis of the brain in Rodentia, Prosimiae and Edentates. Copenhagen 1944.
  • Studies on the morphogenesis of the brain in Hyracoidea, Ungulata, Carnivora and Pinnipedia. Copenhagen 1947.
  • Studies on the morphogenesis of the brain in birds. Copenhagen 1952.
  • Studies on the morphogenesis of the brain in Struthio camelus L. Copenhagen 1956.
  • Studies on the morphogenesis of the brain in some Amphibia, Ascaphus, Rana, Nectophrynoides. Copenhagen 1959.
  • Studies on the brain development of the kiwi, Apteryx mantelli. Copenhagen 1959.
  • Studies on the morphogenesis of the brain in some Urodeles and Gymnophions ("Amphibians"). Copenhagen 1962.

literature

Individual evidence

  1. ↑ a b c Knut H. Krabbe . In: Dansk Biografisk Leksikon .
  2. ↑ a b c d e Krabbe, Knud . In: Kraks Blå Bog. 1957, ISBN 978-87-92211-41-5 .
  3. ^ A b E. D. Louis: The Knud Krabbe (1885-1961) - Henry Alsop Riley (1887-1966) letters (1929-1959): transatlantic friendship fostered by the International Neurological Congresses. In: Journal of medical biography Volume 19, Number 1, February 2011, pp. 26–31, ISSN  1758-1087 . doi : 10.1258 / jmb.2010.010055 . PMID 21350077 , p. 27.
  4. ^ Henry G. Dunn, Eva E. Thomas: Knud Krabbe . In: Stephen Ashwal: The Foundes of child neurology. Norman Publishing, 1990. ISBN 0930405269 , pp. 524f.
  5. ^ Henry G. Dunn, Eva E. Thomas: Knud Krabbe . In: Stephen Ashwal: The Foundes of child neurology. Norman Publishing, 1990, p. 525.
  6. ↑ Knud Krabbe: A new familial, infantile form of diffuse brain-sclerosis. In: Brain . 39, 1916, pp. 74-114, doi : 10.1093 / brain / 39.1-2.74 .
  7. ^ Henry G. Dunn, Eva E. Thomas: Knud Krabbe . In: Stephen Ashwal: The Foundes of child neurology. Norman Publishing, 1990, p. 529.
  8. ↑ T. Schlechinger, T. Fog: Bibliography of the works of Knud H. crab. In: Acta psychiatrica et neurologica Scandinavica Volume 30, Numbers 1-2, 1955, pp. VII-XIX, ISSN  0365-5598 . PMID 13301865 . (Bibliography).
personal data
SURNAME Krabbe, Knud
ALTERNATIVE NAMES Krabbe, Knud Haraldsen (full name)
BRIEF DESCRIPTION Danish neurologist
DATE OF BIRTH March 3, 1885
PLACE OF BIRTH Frederiksberg
DATE OF DEATH May 8, 1961
Place of death Copenhagen