Lactic acidosis
| Classification according to ICD-10 | |
|---|---|
| E87.2 | Acidosis |
| ICD-10 online (WHO version 2019) | |
Lactic acidosis (from lactate and acidosis , also lactic acidosis ) describes a disease state with a low pH value in tissue and blood (acidosis) due to an increased content of lactate (the anion of lactic acid). It is a special form of metabolic acidosis .
Lactic acidosis usually arises from a disturbed cell metabolism , in which the oxygen- consuming ( aerobic ) glucose breakdown cannot take place completely. Lactate then accumulates as an intermediate product of the metabolism, since the energy-generating breakdown of glucose to lactic acid is also possible without oxygen.
In severe cases, lactic acidosis can lead to shock and failure of kidney function .
The signs of lactic acidosis are deep breathing , nausea, and abdominal pain. Because of these unspecific symptoms, lactic acidosis can only be confirmed by laboratory tests . Causes of lactic acidosis can liver - and kidney disease , epileptic seizures or sepsis to be. This clinical picture was described as a drug side effect in biguanides for the treatment of diabetes mellitus (today only metformin ), but also in antiretroviral drugs ( NRTI ) for the treatment of HIV disease or the narcotic propofol (propofol infusion syndrome) in the sense of mitochondrial toxicity .
Lactic acidosis can occur as part of syndromes , as in MLASA .
