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Classification according to ICD-10
E87.2 Acidosis

Diabetic acidosis
ICD-10 online (WHO version 2019)

A acidosis (obsolete also acidosis , from latin acidum "acid") is a disorder of acid-base balance in humans and animals, the lowering of the pH caused in the blood (or other bodily liquids). If the pH value in the blood is below 7.35, it is called acidosis. The reference range in humans is 7.35 to 7.45. If it is higher, one speaks of an alkalosis .

The diet-related acidification of the body (see alkaline diet ), which is sometimes assumed in alternative medicine or complementary medicine, is not based on acidosis.

Major causes


Acidosis represents a respiratory stimulus. Deep breathing ( Kussmaul breathing ) can partially compensate for a non-respiratory acidosis, such as can occur in kidney failure. The compensatory release of hydrogen carbonate by the cells is combined with a release of potassium , which leads to hyperkalemia .

Acidosis inhibits glycolysis and promotes the breakdown of glucose via the pentose phosphate pathway . Acidosis has a negative dromotropic effect on the heart (slower spread of excitation due to the closure of gap junctions ) and negative inotropic (reduced cardiac strength by reducing the likelihood of calcium channels opening ), which together with the vasodilatation caused by the low pH value can result in a drop in blood pressure .


The acidosis is detected by a blood gas analysis . Based on the measurement values of bicarbonate and carbon dioxide - partial pressure in the arterial blood can be distinguished between a respiratory and metabolic disorder. Respiratory acidosis can be recognized by an increased CO 2 partial pressure (PCO 2 ), in metabolic acidosis the standard bicarbonate concentration is lower.


In the case of acidosis, the cause must be eliminated if possible. If the pH value drops below 7.1, a correction can be made with bicarbonate.

See also

Wiktionary: acidosis  - explanations of meanings, word origins, synonyms, translations

Web links

Individual evidence

  1. Richard Daikeler, idols Use, Sylke Waibel: diabetes. Evidence-based diagnosis and therapy. 10th edition. Kitteltaschenbuch, Sinsheim 2015, ISBN 978-3-00-050903-2 , p. 110.