Luteolysis

Processes in the ovary during egg maturation

As luteolysis is called (the breakdown lysis lat. For "Resolution") of the corpus luteum (lat. Corpus luteum ) in the ovary . Luteolysis takes place physiologically in every sexual cycle in the absence of pregnancy or pregnancy . Luteolysis also occurs before birth .

Luteolysis is triggered by the hormone prostaglandin F2α (PGF2α). In addition, cytokines and possibly also gonadoliberin (GnRH) are involved in this process. There is an immigration of macrophages and a breakdown of the capillary network and thus the regression of the corpus luteum. A “white body” ( corpus albicans ) is created through transformation processes .

Luteolysis can be initiated medically by administering prostaglandin F2α or PGF2α analogues ( cloprostenol , tiaprost ). This is mainly done to induce labor or to treat persistent corpuscles .

literature

Hermann M. Behre and Christoph Keck: Endocrinology, reproductive medicine, andrology . Georg Thieme Verlag, 2nd edition 2002, ISBN 9783131071620 , p. 14.