Lymphokines
Lymphokines are a collective name for special cytokines . The original definition of Dumonde (1982) referred to all non antibodies - proteins that activated lymphocytes are produced and as intercellular messengers of the immune response across as lymphokines. This definition is problematic in several respects and has hardly been used since the 1990s .
Two important classes of substances that belong to the lymphokines are the interleukins and the interferons . The first lymphokines were identified in the mid- 1960s , with the best-studied Migration Inhibition Factor (MIF) being described simultaneously by John David and Barry Bloom .
criticism
The problems with Dumondes' definition are that proteins with different functions are grouped together. Many of these lymphokines are produced by cells other than lymphocytes or have other sites of action. Last but not least, the definition is vertebrate- centric: similar proteins in invertebrates are not included because they are not produced by lymphocytes.
Individual evidence
- ^ NA Ratcliffe, AF Rowley, SW Fitzgerald, CP Rhodes: Invertebrate Immunity: Basic Concepts and Recent Advances . In: International Review of Cytology . Vol. 97, 1985, pp. 183-350 , doi : 10.1016 / S0074-7696 (08) 62351-7 .
- ↑ Horst Ibelgaufts: Lymphokines . In: COPE. January 2002, accessed September 3, 2010 .