Ménétrier syndrome

Classification according to ICD-10
K29.6	Other gastritis
ICD-10 online (WHO version 2019)

As ménétrier's disease ( syn .: Crohn Ménétrier , hypertrophic gastropathy Ménétrier , Ménétrier giant folds gastritis , according to Pierre E. Ménétrier, 1859-1935) refers to a disease of the stomach , which is a significant increase in the mucosal folds (10-20 mm ) and widening of the mucous epithelium . The main and parietal cells recede below this. This leads to hypo- to anacidity: too little or no stomach acid is produced. The increased mucus production leads to a loss of protein. Ménétrier syndrome is one of the exudative gastroenteropathies . Histologically, there is foveolar hyperplasia .

The cause is unknown. Helicobacter pylori infection may be a factor. Symptoms are upper abdominal discomfort, nausea and vomiting, diarrhea (caused by the high protein content of the intestinal contents), anemia and edema (due to the enteral protein loss). A malignant degeneration is possible in about 10% of cases. The diagnosis is mainly made through an esophago-gastro-duodenoscopy (EGD) with biopsies . The gastrointestinal passage (MDP), endosonography , a Gordon test and laboratory findings (proteins, electrophoresis, Hb) play a lesser role . Symptoms similar to the syndrome were found in mice whose histamine H2 receptor was switched off.

The diagnosis is to be made in the individual case in the ultrasound , but is made by the gastroscopy .

Treatment is symptomatic and through possible HP eradication . Due to the risk of degeneration, regular check-ups are carried out.

literature

University publications

Georg Kosok: Ménétrier's disease: an epidemiological, clinical and pathological study , 1990, DNB 901542164 (dissertation University of Münster 1990, 141 sheets with illustrations and graphic representations, 30 cm).

Web links

Commons : Ménétrier Syndrome - collection of pictures, videos and audio files

Individual evidence

↑ T. Ogawa, K. Maeda, S. Tonai, T. Kobayashi, T. Watanabe, S. Okabe: Utilization of knockout mice to examine the potential role of gastric histamine H2-receptors in Menetrier's disease . In: J Pharmacol Sci . tape 91 , no. 1 , January 2003, p. 61-70 , PMID 12686732 .
^ B. Zenkl, MM Zieger: Ménétrier disease in a child of 18 months: diagnosis by ultrasonography. In: European Journal of Pediatrics. Volume 147, No. 3, April 1988, ISSN 0340-6199 , pp. 330-331, PMID 3292252 .

[1] T. Ogawa, K. Maeda, S. Tonai, T. Kobayashi, T. Watanabe, S. Okabe: Utilization of knockout mice to examine the potential role of gastric histamine H2-receptors in Menetrier's disease . In: J Pharmacol Sci . tape 91 , no. 1 , January 2003, p. 61-70 , PMID 12686732 .

[2] B. Zenkl, MM Zieger: Ménétrier disease in a child of 18 months: diagnosis by ultrasonography. In: European Journal of Pediatrics. Volume 147, No. 3, April 1988, ISSN 0340-6199 , pp. 330-331, PMID 3292252 .