Metabotropic glutamate receptor 6
| Metabotropic glutamate receptor 6 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 877 amino acids , 95,468 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 2916 | |
| Ensemble | ENSG00000113262 | |
| UniProt | O15303 | |
| Refseq (mRNA) | NM_000843.4 | |
| Refseq (protein) | NP_000834.2 | |
| PubMed search |
2916
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Metabotropic glutamate receptor 6 (GRM 6, mGluR6) is a protein from the group of metabotropic glutamate receptors .
properties
The metabotropic glutamate receptor 6 is a G protein-coupled receptor . It is produced in large quantities in melanocytes . Together with mGluR4 , mGluR7 and mGluR8 it forms group III of the metabotropic glutamate receptors. After binding of glutamate , a change in conformation takes place , which causes signal transduction via G proteins (from the G i family ). As a result, adenylyl cyclase is inhibited. The metabotropic glutamate receptor 6 has disulfide bridges and is glycosylated . It is necessary for eyesight .
Individual evidence
- ↑ a b c d GRM6 - Metabotropic glutamate receptor 6 precursor - Homo sapiens (Human) - GRM6 gene & protein. In: uniprot.org. June 16, 2009, accessed November 6, 2018 .