Metabotropic glutamate receptor 8
| Metabotropic glutamate receptor 8 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 908 amino acids , 101,741 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 2918 | |
| Ensemble | ENSG00000179603 | |
| UniProt | O00222 | |
| Refseq (mRNA) | NM_000845.2 | |
| Refseq (protein) | NP_000836.2 | |
| PubMed search |
2918
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Metabotropic glutamate receptor 8 (GRM 8, mGluR8) is a protein from the group of metabotropic glutamate receptors .
properties
The metabotropic glutamate receptor 8 is a G-protein-coupled receptor . Together with mGluR4 , mGluR6 and mGluR7 it forms group III of the metabotropic glutamate receptors. After binding of glutamate , a change in conformation takes place , which causes signal transduction via G proteins (from the G i family ). As a result, adenylyl cyclase is inhibited. The metabotropic glutamate receptor 8 has disulfide bridges and an isopeptide bond (after ubiquitination ) and is glycosylated .
Ligands
- ( S ) -3,4-DCPG : agonist
Individual evidence
- ↑ a b GRM8 - Metabotropic glutamate receptor 8 precursor - Homo sapiens (Human) - GRM8 gene & protein. In: uniprot.org. September 12, 2018, accessed November 6, 2018 .
- ↑ Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE: (S) -3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord . In: Neuropharmacology . 40, No. 3, 2001, pp. 311-8. doi : 10.1016 / S0028-3908 (00) 00169-6 . PMID 11166323 .