Marco Prince

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Marco Prinz (born July 29, 1970 ) is a German neuropathologist and neuroimmunologist .

From 1990 on, Prinz studied medicine at the Humboldt University Berlin ( Charité ). After completing his doctorate at the Charité in 1996, he worked at the Max Delbrück Center in Berlin (with Helmut Kettenmann ) and from 1999 at the Institute for Neuropathology at the University of Zurich (with Adriano Aguzzi ). From 2002 he was group leader at the Institute for Neuropathology in Göttingen. In 2004 he completed his habilitation in Göttingen and became a senior physician. Since 2008 he has been professor and medical director of the Institute for Neuropathology at the Albert Ludwig University of Freiburg .

It deals with the innate immune system in the central nervous system such as the role of microglia cells and the role of related substances in the immune system such as chemokine receptors , toll-like receptors and cytokines such as interferons . His group is also studying the role of microglia in multiple sclerosis and neurodegenerative diseases such as Alzheimer's . He demonstrated that in the mouse model, cognitive performance in Alzheimer's disease improves when two genes in the microglia are switched off.

Since 2017 he has been the spokesman for the SFB NeuroMac, which is funded with 10.9 million euros, to research the role of microglia cells.

For 2020, Prinz was awarded a Gottfried Wilhelm Leibniz Prize . In 2018 he received the Ernst Jung Prize and in 2014 the Sobek Research Prize . In 2015 he received a Reinhart Koselleck project grant from the DFG .

Fonts (selection)

  • A. Mildner, H. Schmidt, M. Nitsche, D. Merkler, UK Hanisch, M. Mack, M. Heikenwälder, W. Brück, J. Priller, M. Prinz: Microglia in the adult brain arise from Ly-6ChiCCR2 + monocytes only under defined host conditions. In: Nat Neurosc. Volume 10, 2007, pp. 1544-1553.
  • M. Prinz, J. Priller, SS Sisodia, RM Ransohoff: Microglia in the CNS: Heterogeneity of central nervous system myeloid cells and their roles in neurodegeneration. In: Nat Neurosc. Volume 13, 2011, pp. 1227-1235.
  • A. Dann, H. Poeck, A. Croxford, S. Gaupp, K. Kierdorf, M. Knust, D. Pfeifer, C. Maihoefer, S. Endres, U. Kalinke, S. Meuth, H. Wiendl, KP Knobeloch , S. Akira, A. Waisman, G. Hartmann, M. Prinz: Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation of the CNS. In: Nat Neurosc. Volume 15, 2012, pp. 98-106.
  • T. Goldmann, P. Wieghofer, PF Müller, Y. Wolf, D. Varol, S. Yona, SM Brendecke, K. Kierdorf, O. Staszweski, M. Datta, T. Luedde, M. Heikenwalder, S. Jung, M. Prinz: A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. In: Nat Neurosci. Volume 16, 2013, pp. 1618-1626.
  • K. Kierdorf, D. Erny, T. Goldmann, V. Sander, C. Schulz, EG Perdiguero, P. Wieghofer, A. Heinrich, P. Riemke, C. Hölscher, DN Müller, B. Luckow, T. Brocker, K. Debowski, G. Fritz, G. Opdenakker, A. Diefenbach, K. Biber, M. Heikenwalder, F. Geissmann, F. Rosenbauer, M. Prinz: Microglia emerge from erythromyeloid precursors via Pu.1 and IRF-8 dependent pathways. In: Nat Neurosci. Volume 16, 2013, pp. 273-280.
  • M. Prinz, J. Priller: Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. In: Nature Review Neuroscience. Volume 15, 2014, pp. 300-312.
  • D. Erny, AL Hrabě de Angelis, D. Jaitin, P. Wieghofer, O. Staszewski, E. David, H. Keren-Shaul, T. Mahlakoiv, K. Jakobshagen, T. Buch, V. Schwierzeck, O. Utermöhlen , E. Chun, WS Garrett, KD McCoy, A. Diefenbach, P. Staeheli, B. Stecher, I. Amit, M. Prinz: Host microbiota constantly control maturation and function of microglia in the CNS. In: Nat Neurosci. Volume 18, 2015, pp. 965-977.
  • T. Blank, CN Detje, A. Spieß, N. Hagemeyer, SM Brendecke, J. Wolfart, O. Staszewski, T. Zöller, I. Papageorgiou, J. Schneider, R. Paricio-Montesinos, UL Eisel, D. Manahan -Vaughan, S. Jansen, S. Lienenklaus, B. Lu, Y. Imai, M. Müller, SE Goelz, DP Baker, M. Schwaninger, O. Kann, M. Heikenwalder, U. Kalinke, M. Prinz: Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment. In: Immunity. Volume 44, 2016, pp. 901-912.
  • T. Goldmann, P. Wieghofer, MJ Jordão, F. Prutek, N. Hagemeyer, K. Frenzel, L. Amann, O. Staszewski, K. Kierdorf, M. Krueger, G. Locatelli, H. Hochgerner, R. Zeiser , S. Epelman, F. Geissmann, J. Priller, FM Rossi, I. Bechmann, M. Kerschensteiner, S. Linnarsson, S. Jung, M. Prinz: Origin, fate and dynamics of macrophages at central nervous system interfaces. In: Nat Immunol. Volume 17, 2016, pp. 797-805.
  • TL Tay, D. Mai, J. Dautzenberg, F. Fernández-Klett, G. Lin, Sagar, M. Datta, A. Drougard, T. Stempfl, A. Ardura-Fabregat, O. Staszewski, A. Margineanu, A Sporbert, LM Steinmetz, JA Pospisilik, S. Jung, J. Priller, D. Grün, O. Ronneberger, M. Prinz: A new fate mapping system reveals context-dependent random or clonal expansion of microglia. In: Nature Neuroscience. Volume 20, 2017, pp. 793-803.

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personal data
SURNAME Prince, Marco
BRIEF DESCRIPTION German neuropathologist
DATE OF BIRTH July 29, 1970