Margosa extract

safety instructions
Surname	Margosa extract from Azadirachta indica seeds, extracted with supercritical CO 2
CAS number	84696-25-3
GHS labeling of hazardous substances	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
Toxicological data	> 2000 mg kg −1 ( LD 50 , rat , oral ) ; > 2000 mg kg −1 ( LD 50 , rat , transdermal ) ;

As margosa extract , also neem tree extract , vegetable extracts and physically modified derivatives , such as. B. tinctures , solids, vegetable oils, limonoid extracts , limonoid-free extracts, distillates, etc., from components of the neem tree (leaves, bark, seeds, oil, etc.).

Margosa extract and neem oil are often confused with one another, even though they are completely different natural substances. Margosa extract (CAS No. 84696-25-3) is an extract from a component of the neem tree. It is an umbrella term for various natural extracts which z. B. be obtained from the seeds or leaves of the neem tree. With the term margosa extract and its own CAS number , the licensing authorities have made a distinction to normal cold-pressed neem oil (CAS No. 8002-65-1).

composition

Each margosa extract has its own characteristics depending on which part of the neem tree is extracted and depending on which method is used. The components of the extracts differ qualitatively and quantitatively depending on the part of the neem tree used (e.g. leaves, flowers, trunk bark). In addition, the extraction process (e.g. preprocessing, solvent , temperature, final treatment) has a major influence on the constitution of the technical extract.

Types

In the context of the EU biocide regulation, a distinction is made between two types of margosa extract.

Total CO ₂ extract from neem oil

A purified total extract is produced here using the CO ₂ extraction process at a pressure of over 350 bar. This extract is freed from undesirable impurities in the neem oil and is also sterile due to the high pressure in production. Since many of the undesirable, hindering substances are removed in the process, this is a highly effective extract. Even in its pure form, this extract has no hazard labels.

Selective limonoid extract

Above all, azadirachtin, nimbin, salanin are obtained from the neem seeds. The extraction is carried out with water and organic solvents. The end result is a concentrated limonoid active ingredient (predominantly azadirachtin ).

properties

As a technical product, margosa extract is a yellow to brown liquid with a density of 0.925 g · cm ⁻³ and a refractive index of 1.380 (20 ° C). The boiling point is 340 ° C (decomposition), the vapor pressure is 3.8 · 10 ⁻⁷ Pa (20 ° C).

Effects

It is difficult to compare the results of the published literature studies with the results of the studies submitted for the PPP / BPD assessment because they were most often performed with different test compounds. Furthermore, only a few components of the neem tree have been identified. The extracts to be examined consist of several components, e.g. B. Azadirachtin A, Azadirachtin B, Nimbin or Salannin , of which Azadirachtin A has the largest share. Finally, both in the PPP and in the BPD method, the entire extracts were considered to be toxicologically relevant substances, since no toxicological data are available to show that certain components were responsible for the toxicological effects observed. Also aflatoxins could be present as impurities in the relevant excerpts, for them, maximum levels have been defined.

application

The total margosa CO ₂ extract can be used widely. It is an active ingredient that mainly has a repelling effect (i.e. a deterrent / pt. 19 Biocide Regulation) on insects. The application is successful z. B. in anti-mite sprays to combat house dust allergy or in repellants against ticks, fleas, ants, moths etc.

The concentrated azadirachtin active ingredient is mainly used in crop protection, e.g. B. used against frostbite, Colorado beetle or apple aphids. It is also approved for organic farming. It is also an approved biological agent against the oak processionary moth .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ECHA: Proposal for Harmonized Classification and Labeling Margosa Extract, cold-pressed oil of Azadirachta indica seeds without shells extracted with super-critical carbon dioxide , December 2016.
↑ Submitted CLH proposal - MARGOSA EXTRACT, CO2-extract from cold-pressed Neem Seed Oil without shells (Azadirachta indica)
↑ Data sheet Neem bark Extract, aqueous, propyleneglycol containing plant extract from neem bark at Sigma-Aldrich , accessed on July 15, 2017 ( PDF ).
↑ ECHA: Guidance Document on How to utilize PPP Dossiers / Monographs and Existing Substances (ESR) Dossiers / Risk Assessments for the Preparation of BP dossiers / CAs' reports , November 21, 2003

[echa-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ECHA: Proposal for Harmonized Classification and Labeling Margosa Extract, cold-pressed oil of Azadirachta indica seeds without shells extracted with super-critical carbon dioxide , December 2016.

[2] Submitted CLH proposal - MARGOSA EXTRACT, CO2-extract from cold-pressed Neem Seed Oil without shells (Azadirachta indica)

[Sigma-3] Data sheet Neem bark Extract, aqueous, propyleneglycol containing plant extract from neem bark at Sigma-Aldrich , accessed on July 15, 2017 ( PDF ).

[4] ECHA: Guidance Document on How to utilize PPP Dossiers / Monographs and Existing Substances (ESR) Dossiers / Risk Assessments for the Preparation of BP dossiers / CAs' reports , November 21, 2003