Min Chiu Li

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Min Chiu Li

Min Chiu Li ( Chinese  李敏 求 , Pinyin Lǐ Mǐnqiú , * 1919 in Shenyang , Republic of China , † 1980 ) was a Chinese-American doctor ( oncology ). He was the first to succeed in chemotherapy for a widely metastatic, malignant tumor ( chorionic carcinoma ).

Min Chiu Li studied medicine at Mukden Medical College in Shenyang and from 1947 in the USA at the University of Southern California . Since the communists had taken power in mainland China after the Chinese Civil War , he found himself unable to return to his homeland. He completed a residency at the Chicago Presbyterian Hospital (now Rush University Medical Center) and was at what is now the Memorial Sloan-Kettering Cancer Center from 1953 to 1955 . In 1955 he became an assistant to Roy Hertz at the National Cancer Institute . There he developed his methotrexate therapy for chorionic cancer, with which he achieved complete regression in the previously fatal tumor. Since he made the therapy dependent on tumor markers and continued therapy even with invisible symptoms, he came under fire from the National Cancer Institute and was dismissed. He then returned to the Sloan Kettering Center, where he continued his career.

After Sidney Farber discovered folic acid antagonists as chemotherapeutic agents against cancer, which had already been used in the form of methotrexate for breast cancer in the early 1950s ( Jane C. Wright ), Li tested this in chorionic cancer and achieved a complete regression (published 1956). Treatment with methotrexate then became standard therapy. In addition, Li discovered a tumor marker for this type of cancer ( human chorionic gonadotropin , hCG), which was an indication of whether the chemotherapy was successful or had to be continued even in the absence of external symptoms.

In 1960 he published an equally influential paper on combination therapy for testicular cancer , which he showed could be cured by chemotherapy. In 1976 he showed that adjuvant therapy with 5-fluorouracil after surgery for colorectal carcinoma increases the long-term survival probability considerably.

In 1972 he received the Lasker ~ DeBakey Clinical Medical Research Award .

In 1975 he became chairman of the National Cancer Research Committee of the National Science Council of the Republic of China in Taiwan .

Fonts

  • MC Li, R. Hertz, DB Spencer: Effects of methotrexate therapy upon choriocarcinoma and chorioadenoma . In: Proc. Soc. Exp. Biol. Med., Vol. 93, 1956, pp. 361-366.
  • MC Li: The historical background of successful chemotherapy for advanced gestational trophoblastic tumors . In: American Journal of Obstetrics and Gynecology , Volume 135, 1979, pp. 266-272.
  • MC Li, WF Whitmore, R. Golbey, H. Grabstald: Effects of combined drug therapy on metastatic cancer of the testis . In: J. Am. Med. Assoc., Vol. 174, 1960, pp. 1291-1299.

Web links

Individual evidence

  1. ↑ 90 percent of the patients died within one year
  2. ↑ Tumor patients had increased levels of hCG
  3. ^ Min C. Li, Willet F. Whitmore Jr., Robert Golbey, Harry Grabstald: Effects of Combined Drug Therapy on Metastatic Cancer of the Testis . In: JAMA . tape 174 , no. 10 , 1960, p. 1291-1299 , doi : 10.1001 / jama.1960.03030100059013 .
  4. ^ Min C. Li, Stuart T. Ross: Chemoprophylaxis for Patients With Colorectal Cancer: Prospective Study With Five-Year Follow-Up . In: JAMA . tape 235 , no. 26 , 1976, p. 2825-2828 , doi : 10.1001 / jama.1976.03260520019015 .
personal data
SURNAME Li, Min Chiu
BRIEF DESCRIPTION Chinese-American medic
DATE OF BIRTH 1919
PLACE OF BIRTH China
DATE OF DEATH 1980