Trevor's disease ( dysplasia epiphysealis hemimelica , English Trevor disease or Fairbank's disease ) is a congenital disorder of bone development, which is characterized by a circumscribed overgrowth of the cartilaginous structure with deformation and enlargement of one or more bones in the course of ossification . The disease is named after David Trevor. The first description was provided by Albert Mouchet and J. Bélot in 1926. The name "dysplasia epiphysealis hemimelica" was proposed by Fairbank.
The disease is rare, the occurrence is stated to be 1 in 1 million, significantly more common in boys than in girls. The inheritance is autosomal dominant.
M. Trevor usually occurs unilaterally on the lower extremity and leads to malposition and deformation of the joint in the course of growth. Association with enchondromatosis is described. The painless overgrowth is noticeable in early childhood, often on the foot bones, knee or ankle.
The diagnosis can be made on the X-ray based on the typical localization, the irregular overgrowth and the appearance of several non-interconnected bone nuclei attached to the epiphyses . A diagnosis can be confirmed in the MRI .
Bony chippings from previous trauma and synovial chondromatosis due to the age group are to be distinguished.
A causal treatment does not exist, significant disturbing changes can be surgically removed, but grow back again until the skeleton has matured.
- Orphanet "Dysplasia epiphysealis hemimelica"
- A. Oestreich, C. Mitchell, J. Akeson: Both Trevor and Ollier disease limited to one upper extremity. 2002, Skeletal Radiology 31, p. 230
- TJ FAIRBANK: dysplasia epiphysialis hemimelica (tarso-ephiphysial aclasis). In: The Journal of bone and joint surgery. British volume. Volume 38-B, Number 1, February 1956, pp. PMID 13295331 . , .
- emedicine review article
- J. Bürgler, F. Fernandez, T. Wirth: Dysplasia epiphysealis hemimelica (Trevor's disease). Cases and their courses
- Radiopaedia Dysplasia-epiphysealis-hemimelica