Synovial chondromatosis

from Wikipedia, the free encyclopedia
Classification according to ICD-10
M67.8 Other specified diseases of synovium and tendons
ICD-10 online (WHO version 2019)

The synovial chondromatosis is a rare disease of the synovium of large joints. It is a cartilage- forming metaplasia ( chondromatosis ). The first case reports come from Paul Friedrich Reichel , Melvin Starkey Henderson (1918) and Hugh Toland Jones (1924). The cause is still unclear.

Pathology and clinic

Chondromatosis of the hip joint

Pathological-anatomical it is a metaplasia of mesenchymal cells in circumscribed cartilage areas. In men, the rare clinical picture occurs about twice as often as in women, in children only sporadically.

The knee, hip, shoulder and elbow joints are “often” affected. The temporomandibular joint can also be affected.

Most patients are relatively symptom-free for a long time. Finally, entrapment symptoms, mobility impairment or pain from free joint bodies and synovial chondromas, as well as possible damage to joint structures through abrasion ( secondary arthrosis ) require clarification.

Diagnosis and therapy

Chondromatosis of the elbow joint

Synovial chondromatosis is a radiological visual diagnosis. A dreaded complication is the development of a secondary chondrosarcoma . In a larger study of 53 cases in 30 years, three chondrosarcomas were diagnosed.

Sperling and co-workers cite a publication by Blokx and co-workers, according to which a total of 34 chondrosarcomas had been described in connection with synovial chondromatosis by the year 2000.

The treatment of synovial chondromatosis consists in the most complete open synovialectomy possible .

Giant solitary synovial chondromatosis

In this sub-form, many individual chondromas merge, so that a solid tumor can develop up to a diameter of 20 cm. A corresponding enlargement of a single chondroma is also considered possible. Differentiation from chondrosarcoma is difficult histologically and radiologically.

See also


  • RI Davis, A. Hamilton, JD Biggart: Primary synovial chondromatosis: a clinicopathologic review and assessment of malignant potential. In: Human Pathology . 29 (1998), pp. 683-688.

Web links

Commons : Synovial Chondromatosis  - collection of images, videos and audio files

Individual evidence

  1. ^ PF Reichel: Chondromatosis of the knee joint capsule. In: Archives for Clinical Surgery .
  2. ^ Anton Sebastian: A Dictionary of the History of Medicine.
  3. ^ Reichel's syndrome
  4. ^ A b R. I. Davis, A. Hamilton, JD Biggart: Primary synovial chondromatosis: a clinicopathologic review and assessment of malignant potential. In: Hum Pathol . 1998 Jul; 29 (7), pp. 683-688. PMID 9670824
  5. ^ E. Ko, E. Mortimer, AE Fraire: Extraarticular synovial chondromatosis: review of epidemiology, imaging studies, microscopy and pathogenesis, with a report of an additional case in a child. In: Int. J. Surg. Pathol. 12 (2004), pp. 273-280. PMID 15306942
  6. T. Mueller, T. Barthel, A. Cramer, A. Werner, F. Gohlke: Primary synovial chondromatosis of the elbow. In: Journal of Shoulder and Elbow Surgery 9 (2000), pp. 319-322. PMID 10979529
  7. ^ AB Holmlund, L. Eriksson, FP Reinholt: Synovial chondromatosis of the temporomandibular joint: clinical, surgical and histological aspects. In: Int. J. Oral Maxillofac. Surg. 32 (2003), pp. 143-147. PMID 12729773
  8. Jun-ichi Koyama, Jusuke Ito, Takafumi Hayashi, Fukiko Kobayashi: Synovial Chondromatosis in the Temporomandibular Joint Complicated by Displacement and Calcification of the Articular Disk: Report of Two Cases. In: American Journal of Neuroradiology. 22 (2001), pp. 1203-1206.
  9. A. Hamilton, RI Davis, D. Hayes, RA Mollan: Chondrosarcoma developing in synovial chondromatosis. A case report. ( Memento of the original from January 9, 2009 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. In: Journal of Bone and Joint Surgery. - British Volume, Vol 69-B, Issue 1, 1987, pp. 137-140. @1@ 2Template: Webachiv / IABot /
  10. P. Anract, M. Katabi, M. Forest, J. Benoit, J. Witvoët, B. Tomeno: Synovial chondromatosis and chondrosarcoma. A study of the relationship between these two diseases. In: Rev Chir Orthop Reparatrice Appar Mot. 1996; 82 (3), pp. 216-224. PMID 9005459 (French)
  11. B. Sperling, S. Angel, G. Stoneham, V. Chow, A. McFadden, R. Chibbar: Synovial chondromatosis and chondrosarcoma: a diagnostic dilemma . In: Sarcoma. 7 (2003), pp. 69-73.
  12. WAM Blokx, LAJ Rasing, RPH Beth, M. Pruszczynski: Late malignant transformation of biopsy proven benign synovial chondromatosis: an unexpected pitfall. In: Histopathology . 36 (2000), pp. 564-572. doi : 10.1046 / j.1365-2559.2000.00918.x
  13. J. Edeiken, BS Edeiken, AG Ayala, AK Raymond, JA Murray, SQ Guo: Giant solitary synovial chondromatosis. In: Skeletal Radiol. 23 (1994), pp. 23-29. PMID 8160032