Myokines

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Myokines are hormone-like messenger substances that are released by the muscles of mammals during movement and contraction . The name is derived from the Greek "Mys": muscle and "kinema": movement. Since 2007 they have been classified as a subspecies of the interleukins (IL-x), peptide hormones belonging to the cytokines , ie they are classified as the body's own messenger substances of the muscle cells. Their discovery goes back to the Center of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Center, Rigshospitalet , University of Copenhagen, Faculty of Health Sciences, in Denmark. There are over 600 different species listed, not all of which have been fully explored. They represent a current research area in cell biology .

effect

So far, effects on type II diabetes , the cardiovascular system , the metabolism and the elasticity of vessels are known.

swell

  1. ^ Center of Inflammation and Metabolism: About CIM
  2. ↑ JH Lee, HS Jun: Role of Myokines in Regulating Skeletal Muscle Mass and Function . In: Frontiers in Physiology . tape 10 , 2019, pp. 42 , doi : 10.3389 / fphys.2019.00042 , PMID 30761018 .
  3. ↑ Christa Broholm, Matthew J. Laye, Claus Brandt, Radhika Vadalasetty, Henriette Pilegaard, Bente Klarlund Pedersen, Camilla Scheele: LIF is a contraction-induced myokine stimulating human myocyte roliferation . In: Journal of Applied Physiology . 2011; 111: 251-259. doi : 10.1152 / japplphysiol.01399.2010
  4. ↑ Bente Klarlund Pedersen, Thorbjörn CA Åkerström, Anders R. Nielsen and Christian P. Fischer: Role of myokines in exercise and metabolism. (PDF; 69 kB) In: J Appl Physiol 103: 1093-1098, 2007. doi : 10.1152 / japplphysiol.00080.2007
  5. ^ E. Wolsk, H. Mygind, TS Grøndahl, BK Pedersen, G. van Hall: IL-6 selectively stimulates fat metabolism in human skeletal muscle. In: American Journal of Physiology-Endocrinology and Metabolism . 2010; 299: p. E832 – E840, doi : 10.1152 / ajpendo.00328.2010 . PMID 20823453 .
  6. ^ C. Brandt, BK Pedersen: The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. In: Journal of biomedicine & biotechnology. Volume 2010, 2010, p. 520258, ISSN  1110-7251 . doi : 10.1155 / 2010/520258 . PMID 20224659 . PMC 2836182 (free full text). (Review).

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