N -phenylpropenoyl- L -amino acid amides

Structural formula of N -coffee acid- L -aspartic acid amide

N -Phenylpropenoyl- L -amino acid amides are a group of phytochemicals that were isolated for the first time in 2005. These are phenylpropanoid acids that are amidated with various amino acids .

Occurrence

Ivy ( Hedera helix )

The substance class is found in various plants such as the medicinal angelica ( Angelica archangelica ), the coriander ( Coriandrum sativum ), the seeds of the cocoa tree ( Theobroma cacao ), the leaves of the ivy ( Hedera helix ) and the black elder ( Sambucus nigra ).

effect

In cell cultures two stimulate the substances from this group [ N - ( E ) -Kaffeesäure- L -asparaginsäureamid and N - ( E ) -Kaffeesäure- L -tryptophanamid] both the mitochondrial activity and the proliferation rate of human liver cells and horn forming skin cells . Another component reduced the adhesion of Helicobacter pylori to human gastric mucosal cells.

literature

T. Stark, T. Hofmann: Isolation, structure determination, synthesis, and sensory activity of N-phenylpropenoyl-L-amino acids from cocoa (Theobroma cacao) . In: Journal of Agricultural and Food Chemistry . tape 53 , no. 13 , 2005, pp. 5419-5428 , doi : 10.1021 / jf050458q , PMID 15969528 .
T. Stark, et al .: Quantitative analysis of N-phenylpropenoyl-L-amino acids in roasted coffee and cocoa powder by means of a stable isotope dilution assay . In: Journal of Agricultural and Food Chemistry . tape 54 , no. 8 , 2006, p. 2859-2867 , doi : 10.1021 / jf053207q , PMID 16608201 .

Individual evidence

↑ ^a ^b A. Hensel, et al .: Occurrence of N-phenylpropenoyl-L-amino acid amides in different herbal drugs and their influence on human keratinocytes, on human liver cells and on adhesion of Helicobacter pylori to the human stomach . In: Planta Medica . tape 73 , no. 2 , February 2007, p. 142-150 , doi : 10.1055 / s-2006-957079 , PMID 17295182 .
↑ T. Stark, et al .: Absorption of N-phenylpropenoyl-L-amino acids in healthy humans by oral administration of cocoa (Theobroma cacao) . In: Molecular Nutrition & Food Research . tape 52 , no. 10 , October 2008, p. 1201-1214 , doi : 10.1002 / mnfr.200700447 , PMID 18646003 .

[q1-1] A. Hensel, et al .: Occurrence of N-phenylpropenoyl-L-amino acid amides in different herbal drugs and their influence on human keratinocytes, on human liver cells and on adhesion of Helicobacter pylori to the human stomach . In: Planta Medica . tape 73 , no. 2 , February 2007, p. 142-150 , doi : 10.1055 / s-2006-957079 , PMID 17295182 .

[2] T. Stark, et al .: Absorption of N-phenylpropenoyl-L-amino acids in healthy humans by oral administration of cocoa (Theobroma cacao) . In: Molecular Nutrition & Food Research . tape 52 , no. 10 , October 2008, p. 1201-1214 , doi : 10.1002 / mnfr.200700447 , PMID 18646003 .