Tachykinin receptor
Tachykinin receptors , also called neurokinin receptors or NK receptors for short , are proteins on the surface membrane of cells in tissue animals , which are activated by the body's own messenger substances from the group of tachykinins . The three known human tachykinin receptors, NK 1 , NK 2 and NK 3 , have a selectivity for the tachykinins substance P , neurokinin A and neurokinin B and are also found in other mammals . All known tachykinin receptors belong to the group of G protein-coupled receptors and activate a signal transmission cascade involving heterotrimeric G proteins of the G q / 11 type . The activation of tachykinin receptors plays an important role in pain perception , among other things . With aprepitant a tachykinin retardant is drugs as an antiemetic used.
| NK 1 | NK 2 | NK 3 | |
|---|---|---|---|
| genetics | |||
| Gene name | TACR1 | TACR2 | TACR3 |
| Gene locus | 2p13.1-p12 | 10q11-q21 | 4q24 |
| protein | |||
| UniProt-Bez. | P25103 | P21452 | P29371 |
| structure | 7TM | 7TM | 7TM |
| length | 407 amino acids | 398 amino acids | 465 amino acids |
| physiology | |||
| function |
Pain perception inflammation |
Micturition reflex | |
| Signal transduction | G q / 11 | G q / 11 | G q / 11 |
| pharmacology | |||
| Agonists |
Substance P septid |
Neurokinin A |
Neurokinin B Senkrid |
| Antagonists |
Aprepitant Befetupitant Casopitant Dapitant ezlopitant Figopitant fosaprepitant Lanepitant tradipitant maropitant Netupitant Orvepitant Rolapitant Serlopitant Vestipitant Vofopitant |
Ibodutant Saredutant |
Osanetant Talnetant |
literature
- Alexander SP: 7TM receptors . In: British Journal of Pharmacology . 158, 2009, pp. S5-S101. doi : 10.1111 / j.1476-5381.2009.00501.x .
Individual evidence
- ↑ IPR001681 Neurokinin receptor. In: InterPro 30.0. EBI, accessed January 22, 2011 .