Neurokinin B

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Neurokinin B
Neurokinin B
Structural formula

Existing structural data : 1p9f

Properties of human protein
Mass / length primary structure 10 amino acids, 1210 Da
Precursor Tachykinin-3 (100 aa)
Identifier
Gene name TAC3
External IDs
Occurrence
Parent taxon Mammals

Neurokinin B (NKB) is a neuropeptide from the tachykinin family , which is held responsible for triggering puberty .

Neurokinin B is mainly produced in nerve cells in the hypothalamus . The cells that produce neurokinin B are in turn located near nerve cells that trigger the release of sex hormones from the pituitary gland during puberty.

structure

The primary structure of the human neurokinin B consists of 10 amino acids (decapeptide), which consists of the prohormone protachykinin processed is.

Discovery of the puberty-inducing effects

Four Turkish families, whose children never reached puberty , contributed to the discovery of the messenger substance .

Individual evidence

  1. ↑ Homologues at OMA
  2. ↑ Data sheet Neurokinin B from Sigma-Aldrich , accessed on June 15, 2011 ( PDF ).
  3. ↑ Primary structure: Asp - Met - His - Asp - Phe - Phe - Val - Gly - Leu - Met -NH 2
  4. ↑ Mantha, AK et al. (2004): Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles. In: J. Biomol. Struct. Dyn. 22 (2): 137-148. PMID 15317475
  5. ↑ Topaloglu, AK et al. (2008): TAC3 and TACR3 Mutations in Familial Hypogonadotropic Hypogonadism Reveal a Key Role for Neurokinin B in the Central Control of Reproduction. In: Nat. Genet. PMID 19079066 doi : 10.1038 / ng.306 Supplementary Notes (PDF)

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