Noxious toxin

Noxious toxin
other names	Potassium channel toxin alpha-KTx 2.1, NTx, Toxin II.11
	Existing structure data : PDB 1SXM
Mass / length primary structure	39 amino acids , 4,202 Da
Identifier
External IDs	UniProt : P08815 ;

Noxiustoxin (synonym Kaliumkanaltoxin alpha-KTx 2.1 ) is a neurotoxin from the Mexican scorpion Centruroides noxius .

properties

Noxiustoxin is a peptide and a scorpion toxin from the venom of Centruroides noxius , like Slotoxin . It binds to voltage-gated and calcium-gated potassium channels and blocks them, including the voltage-gated mKv1.1 / KCNA1 ( Kd > 25 nM ), rKv1.2 / KCNA2 (Kd = 2 nM), mKv1.3 / KCNA3 (Kd = 1 nM), hKv1.5 / KCNA5 (Kd> 25 nM) and mKv3.1 / KCNC1 (Kd> 25 nM) as well as the calcium-dependent KCa1.1 / KCNMA1 and KCa3.1 / KCNN4 (Kd> 25 nM). Noxiustoxin is amidated . It is structurally related to charybdotoxin a and charybdotoxin b .

Web links

MeSH noxious toxin

Individual evidence

↑ ^a ^b ^c H. H. Valdivia, JS Smith, BM Martin, R. Coronado, LD Possani: Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K + (Ca2 +) channel. In: FEBS letters. Volume 226, Number 2, January 1988, pp. 280-284, PMID 2448164 .
↑ S. Grissmer, AN Nguyen, J. Aiyar, DC Hanson, RJ Mather, GA Gutman, MJ Karmilowicz, DD Auperin, KG Chandy: Pharmacological characterization of five cloned voltage-gated K + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. In: Molecular pharmacology. Volume 45, Number 6, June 1994, pp. 1227-1234, PMID 7517498 .

[Valdivia-1] H. H. Valdivia, JS Smith, BM Martin, R. Coronado, LD Possani: Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K + (Ca2 +) channel. In: FEBS letters. Volume 226, Number 2, January 1988, pp. 280-284, PMID 2448164 .

[2] S. Grissmer, AN Nguyen, J. Aiyar, DC Hanson, RJ Mather, GA Gutman, MJ Karmilowicz, DD Auperin, KG Chandy: Pharmacological characterization of five cloned voltage-gated K + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. In: Molecular pharmacology. Volume 45, Number 6, June 1994, pp. 1227-1234, PMID 7517498 .