Slotoxin

Potassium channel toxin alpha-KTx 1.11
other names	Slotoxin
Mass / length primary structure	37 amino acids , 4,092 Da
Identifier
External IDs	UniProt : P0C182 ;

Slotoxin (synonymous with potassium channel toxin alpha-KTx 1.11 ) is a neurotoxin from the scorpion Centruroides noxius .

properties

Slotoxin is a peptide and a scorpion toxin from the venom of Centruroides noxius , as is Noxiustoxin . It binds to calcium-controlled potassium channels and blocks KCa1.1 / KCNMA1 reversibly and KCNMA1 and KCNMB1 and, to a lesser extent, KCNMA1 and KCNMB4 , but not dSlo , Kv1.1 / KCNA1 , Kv11.1 / KCNH2 / KCNJ12.2 , Kir2.2 , Shaker-IR , SK1 / KCNN1 , SK2 / KCNN2 and SK3 / KCNN3 . Slotoxin is structurally related to charybdotoxin (αKTx1 family).

Web links

MeSH slotoxin

Individual evidence

↑ J. Garcia-Valdes, FZ Zamudio, L. Toro, LD Possani, LD Possan: Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha + beta (beta1 or beta4) complexes. In: FEBS letters. Volume 505, Number 3, September 2001, pp. 369-373, PMID 11576530 .

[1] J. Garcia-Valdes, FZ Zamudio, L. Toro, LD Possani, LD Possan: Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha + beta (beta1 or beta4) complexes. In: FEBS letters. Volume 505, Number 3, September 2001, pp. 369-373, PMID 11576530 .