Ocinaplone

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Structural formula
Structure of ocinaplone
General
Non-proprietary name Ocinaplone
other names
  • Pyridin-2-yl- (7-pyridin-4-ylpyrazolo- [1,5- a ] -pyrimidin-3-yl) methanone ( IUPAC )
  • 2-pyrinyl [7- (4-pyrelinyl) pyrazolo [1,5- a ] pyrimidin-3-yl]
Molecular formula C 17 H 11 N 5 O
External identifiers / databases
CAS number 96604-21-6
PubChem 216456
ChemSpider 187602
DrugBank DB06529
Wikidata Q2013712
Drug information
ATC code

not allowed

Drug class

Psychotropic drugs

properties
Molar mass 301.30 g mol −1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Ocinaplone (manufacturer DOV Pharm. Inc. ) is a drug from the group of psychotropic drugs that should be used to treat anxiety . Its development was stopped in clinical phase III in 2005 .

Pharmacological properties

Mechanism of action (pharmacodynamics)

Ocinaplone has a similar effect to benzodiazepines . It binds allosterically to GABA receptors and thus strengthens their function.

In contrast to the benzodiazepines, ocinaplone does not sedate the patient, nor does it show any impairment of motor skills.

Side effects

Ocinaplone led to an increase in the activity of liver enzymes , which is why its development was stopped in 2005.

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

literature

pharmacology

  • Chilman-Blair et al., Ocinaplon: treatment of generalized anxiety disorder GABA-A receptor modulator ., In Drugs of the Future , 28/2, 2003, pp. 115-120