Oliver Semler

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Jörg Oliver Semler (born October 31, 1974 in Stuttgart ) is a German pediatrician and scientist in the field of osteogenesis imperfecta (glass bone disease).

Life

Oliver Semler was born with the hereditary disease osteogenesis imperfecta (glass bone disease). From childhood and adolescence he suffered around 30 broken bones to this day. His growth was also greatly inhibited by the disease, so that he only reached a height of 1.40 meters. After graduating from high school, he studied medicine in Cologne and Freiburg i. Br. And went through the specialist training to become a pediatrician.

Even in his doctoral thesis , Semler dealt with the glass bone disease. In 2001 he received his doctorate at the University of Heidelberg and began his career at the Saarland University Clinic in Homburg / Saar . In 2004 he took up a position in the children's clinic at Cologne University Hospital . There he played a key role in setting up an outpatient clinic for patients with vitreous bone disease, which he manages. At the association level and in public, Semler advocates the concerns of patients with vitreous bone disease.

In addition to his clinical work, Semler researches the causes and treatment options of osteogenesis imperfecta. 2013 he has with the subject imperfecta Translational research into osteogenesis: From Pathogenesis to Targeted Therapies habilitation . He then became the spokesman for the Center for Rare Skeletal Diseases in Children and Adolescents, which was established at the Clinic and Polyclinic for Pediatric and Adolescent Medicine at the University Hospital Cologne.

Awards

  • 2003: Doctoral award from the German Society for Osteogenesis Imperfecta
  • 2005: Steps Award of the Pediatric Endocrinology Working Group
  • 2008: Klaus Kruse grant from the Pediatric Endocrinology Working Group
  • 2009: Integration award from the social association VdK North Rhine-Westphalia
  • 2011: Jürgen Bierich Prize (experimental part) of the Pediatric Endocrinology and Diabetology Working Group
  • 2011: Faculty award for the best publication from the University Hospital Cologne
  • 2012: Eva Luise Köhler Research Award for Rare Diseases
  • 2014: Friedrich Linnweh Prize of the 50th Annual Meeting for Pediatric Research
  • 2014: Young Investigator Award from the European Society of Pediatric Endocrinology
  • 2017: HanseMerkur Prize for Child Protection

Publications (selection)

  • with MS Cheung, FH Glorieux, F. Rauch: Wormian bones in osteogenesis imperfecta: Correlation to clinical findings and genotype. In: Am. J. Med. Genet. A. 152A, 2010, pp. 1681-1687, PMID 20583157 .
  • with R. Beccard, D. Palmisano, A. Demant, O. Fricke, E. Schoenau, F. Koerber: Reshaping of vertebrae during treatment with neridronate or pamidronate in children with osteogenesis imperfecta. In: Horm Res Pediatr. 76, 2011, pp. 321-327, PMID 21952409 .
  • with C. Netzer, H. Hoyer-Kuhn, J. Becker, P. Eysel, E. Schoenau: First use of the RANKL antibody denosumab in osteogenesis imperfecta type VI. In: J Musculoskelet Neuronal Interact. 12, 2012, pp. 183-188, PMID 22947550 .
  • with L. Garbes, K. Keupp, D. Swan, K. Zimmermann, J. Becker, S. Iden, B. Wirth, P. Eysel, F. Koerber, E. Schoenau, SK Bohlander, B. Wollnik, C. Netzer: A mutation in the 5'-UTR of IFITM5 creates an in-frame start codon and causes autosomal-dominant osteogenesis imperfecta type V with hyperplastic callus. In: Am. J. Hum. Genet .. 91, 2012, pp. 349-357, PMID 22863195 PMC 3415541 (free full text).
  • with H. Hoyer-Kuhn, L. Garbes, K. Zimmermann, J. Becker, B. Wollnik, E. Schoenau, C. Netzer: A nonclassical IFITM5 mutation located in the coding region causes severe osteogenesis imperfecta with prenatal onset. In: J. Bone Miner. Res. 29, 2014, pp. 1387-1391, PMID 24293101 .
  • with H. Hoyer-Kuhn, C. Stark, N. Struebing, O. Goebel, E. Schoenau: A specialized rehabilitation approach improves mobility in children with osteogenesis imperfecta. In: J Musculoskelet Neuronal Interact. 14, 2014, pp. 445-453, PMID 25524970 .
  • with H. Hoyer-Kuhn, J. Franklin, G. Allo, M. Kron, C. Netzer, P. Eysel, B. Hero, E. Schoenau: Safety and efficacy of denosumab in children with osteogenesis imperfect - a first prospective trial. In: J Musculoskelet Neuronal Interact. 16, 2016, pp. 24-32, PMID 26944820 PMC 5089451 (free full text).
  • with JC Marini, A. Forlino, HP Bächinger, NJ Bishop, PH Byers, A. Paepe, F. Fassier, N. Fratzl-Zelman, KM Kozloff, D. Krakow, K. Montpetit: Osteogenesis imperfecta. In: Nat Rev Dis Primers. 3, 2017, pp. 17052-17052, PMID 28820180 .

Individual evidence

  1. ^ Heidrun Wulf-Frick: A career with a handicap. In: Zeit Online . February 4, 2010.
  2. ^ H. Zankl, Oliver Semler: Pediatrician with glass bones . In: H. Zankl, K. Betz: Nevertheless genial . Wiley-VCH, Weinheim 2014, pp. 193–198.
  3. ↑ The complex treatment of glass bones. WDR 2017.
  4. ↑ NN: Important academic milestone for Dr. Oliver Semler. In: Breakthrough , No. 3/2013, p. 5.
  5. ^ Center for Rare Skeletal Diseases in Children and Adolescents.
personal data
SURNAME Semler, Oliver
ALTERNATIVE NAMES Semler, Jörg Oliver (full name)
BRIEF DESCRIPTION German medic
DATE OF BIRTH October 31, 1974
PLACE OF BIRTH Stuttgart