Oncostatin-M

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Oncostatin-M

Existing structural data : 1evs

Properties of human protein
Mass / length primary structure 209 amino acids
Identifier
Gene name OSM
External IDs
Occurrence
Homology family Oncostatin-M
Parent taxon Higher mammals

Oncostatin-M (OSM) is a protein produced by mammals in activated leukocytes . It is a cytokine that is part of the signaling cascade that controls hematopoiesis . In addition, OSM is involved in the inflammatory response . It is capable of the sprouting of several cancer - cell lines to influence positive or negative.

OSM is produced in the bone marrow and lymphatic system in direct response to IL-2 , IL-3 and EPO . In turn, it exerts its effects on OSM receptors , of which there are two types. OSM stimulates the growth of endothelial cells and their production of plasminogen activator , G-CSF , GM-CSF , P-selectin and IL-6 . OSM belongs to the IL-6 subfamily of cytokines.

Individual evidence

  1. ↑ UniProt P13725
  2. ↑ H. Ibelgaufts / COPE: Oncostatin-M
  3. ↑ Yao L, Pan J, Setiadi H, Patel KD, McEver RP: Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells . In: J. Med.. . 184, No. 1, July 1996, pp. 81-92. PMID 8691152 . PMC 2192668 (free full text).
  4. ↑ Hams E, Colmont CS, Dioszeghy V, et al : Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation . In: J. Immunol. . 181, No. 3, August 2008, pp. 2174-80. PMID 18641356 .
  5. ↑ Mozaffarian A, Brewer AW, Trueblood ES, et al : Mechanisms of oncostatin M-induced pulmonary inflammation and fibrosis . In: J. Immunol. . 181, No. 10, November 2008, pp. 7243-53. PMID 18981146 .
  6. ↑ Hintzen C, Haan C, Tuckermann JP, Heinrich PC, Hermanns HM: Oncostatin M-induced and constitutive activation of the JAK2 / STAT5 / CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression . In: J. Immunol. . 181, No. 10, November 2008, pp. 7341-9. PMID 18981157 .