Platelet selectin

P-selectin
other names	CD62 antigen-like family member P, Granule membrane protein 140, GMP-140
	Existing structure data : PDB 1FSB , PDB 1G1Q , PDB 1G1R
Properties of human protein
Mass / length primary structure	830 amino acids , 90,834 Da
Identifier
External IDs	GeneCards : SELP ; OMIM : 173610 ; UniProt : P16109 ;
	Orthologue (human)
Entrez	6403
Ensemble	ENSG00000174175
UniProt	P16109
Refseq (mRNA)	NM_003005.3
Refseq (protein)	NP_002996.2
PubMed search	6403

Platelet selectin (synonym P-selectin , P-selectin , CD62P from English platelet 'thrombocyte') is a surface protein from the group of selectins .

properties

P-selectin is a lectin and participates in cell adhesion in an immune reaction . It mediates Ca ²⁺ -dependent cell contacts between leukocytes and endothelial cells or platelets by binding to sialyl-Lewis X . It is stored in alpha granules and Weibel-Palade bodies in the endothelial cells until the endothelial cell is activated . It then participates in the rolling of the leukocytes along the cell surface by binding to PSGL1 . P-selectin is glycosylated and palmitoylated .

P-selectin is involved in the decreased blood flow in sickle cell anemia .

Web links

MeSH platelet selectin

Individual evidence

↑ A. Kutlar, SH Embury: Cellular adhesion and the endothelium: P-selectin. In: Hematology / oncology clinics of North America. Volume 28, Number 2, April 2014, pp. 323-339, doi : 10.1016 / j.hoc.2013.11.007 , PMID 24589269 .

[1] A. Kutlar, SH Embury: Cellular adhesion and the endothelium: P-selectin. In: Hematology / oncology clinics of North America. Volume 28, Number 2, April 2014, pp. 323-339, doi : 10.1016 / j.hoc.2013.11.007 , PMID 24589269 .