Oxyntomodulin
| Glucagon precursor protein - the precursor protein of oxyntomodulin | ||
|---|---|---|
| other names |
Incretin hormone, glucagon |
|
| Properties of human protein | ||
| Mass / length primary structure | 180 amino acids , 20,909 da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 2641 | |
| Ensemble | ENSG00000115263 | |
| UniProt | P01275 | |
| Refseq (mRNA) | NM_002054.4 | |
| Refseq (protein) | NP_002045.1 | |
| PubMed search |
2641
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Oxyntomodulin (abbreviated to Oxm , Oxy ) is a peptide hormone that is released in the small intestine by so-called L cells during food intake and plays a role in people's feeling of satiety and appetite .
Oxyntomodulin is used experimentally for drug-assisted weight loss in the case of obesity , as it cushions feelings of hunger . Oxyntomodulin injected before meals caused weight loss in subjects. Furthermore, Oxyntomodulin promotes energy turnover.
It is believed that the hormone acts on the GLP-1 receptor ( glucagon-like peptide 1 receptor ). Like 7 other peptides - glucagon , glicentin, glicentin-related polypeptide (GRPP), glucagon-like peptide 1 (GLP-1, incretin hormone), glucagon-like peptide 1 (7-37), glucagon-like peptide 1 ( 7-36), Glucagon-like peptide 2 (GLP-2) - oxyntomodulin is produced by proteolysis from the glucagon precursor protein .
Amino acid sequence (human)
Oxyntomodulin has the amino acid sequence :
H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln- Trp-Leu-Met-Asn-Thr-Lys-Arg-Asn-Arg-Asn-Asn-Ile-Ala-OH
See also
Individual evidence
- ↑ Baynes KC Dhillo WS Bloom SR: Regulation of food intake by gastrointestinal hormones . In: Curr Opin Gastroenterol . 2006; 22: 626-631.
- ↑ Wynne K et al .: Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomized controlled trial . In: International Journal of Obesity , 2006, 30, 1729-1736, doi : 10.1038 / sj.ijo.0803344 .
- ↑ GCG - Glucagon precursor - Homo sapiens (Human) - GCG gene & protein. In: uniprot.org. June 20, 2018, accessed May 24, 2018 .
- ↑ Entry on Oxyntomodulin. In: Römpp Online . Georg Thieme Verlag, accessed on July 17, 2014.
literature
- MR Druce, SR Bloom: Oxyntomodulin: a novel potential treatment for obesity. In: Treatments in endocrinology. Volume 5, Number 5, 2006, pp. 265-272, ISSN 1175-6349 . PMID 17002486 .
- K. Wynne, AJ Park, CJ Small, M. Patterson, SM Ellis, KG Murphy, AM Wren, GS Frost, K. Meeran, MA Ghatei, SR Bloom: Subcutaneous Oxyntomodulin Reduces Body Weight in Overweight and Obese Subjects: A Double- Blind, randomized, controlled trial. In: Diabetes . 54, 2005, pp. 2390-2395, doi : 10.2337 / diabetes.54.8.2390 .