PKCζ
| Protein kinase C zeta type ( Homo sapiens ) | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 67.6 kD / 592 amino acids | |
| Identifier | ||
| Gene name | PRKCZ | |
| External IDs | ||
| Drug information | ||
| DrugBank | DB00675 | |
| Enzyme classification | ||
| EC, category | 2.7.11.13 | |
| Occurrence | ||
| Parent taxon | Chordates | |
PKCζ (synonym protein kinase Cζ , PKCzeta ) is an enzyme from the group of protein kinases It is an atypical isoform of protein kinase C . After PKCζ proteolysis , the protein kinase Mζ , also PKMζ , is produced, which plays a role in memory and memory processes.
PKMζ was discovered in 1993 by Todd Charlton Sacktor and coworkers at Downstate Medical Center in New York. PKMζ is a fragment produced by cleavage of the protein kinase Cζ and plays an important role at the synapses, the connection points between the nerve cells . It is generally responsible for the storage of memories in long-term memory . It is responsible for storing both pleasant and unpleasant memory contents, regardless of whether they concern location, activities or events.
Local inhibition of PKMzeta in different brain regions of rats and mice leads to the deletion of trained memory contents (sometimes up to several months after training). The discovery, published in 2006, that it keeps memories stable and thus strengthens long-term memory, was one of the 10 breakthroughs of 2006 in the journal Science.
Individual evidence
- ^ TC Sacktor, P. Osten, H. Valsamis, X. Jiang, MU Naik, E. Sublette: Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation. In: Proc Natl Acad Sci USA . 90, 1993, pp. 8342-8346.
- ↑ P. Serrano, EL Friedman, J. Kenney et al .: PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories . In: PLoS Biol . tape 6 , no. December 12 , 2008, pp. 2698-2706 , doi : 10.1371 / journal.pbio.0060318 , PMID 19108606 , PMC 2605920 (free full text).
- ↑ AI Hernandez, N. Blace, JF Crary et al: Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory . In: J. Biol. Chem. Volume 278 , no. 41 , October 2003, p. 40305-40316 , doi : 10.1074 / jbc.M307065200 , PMID 12857744 .
- ↑ E. Pastalkova, P. Serrano, D. Pinkhasova, E. Wallace, AA Fenton, TC Sacktor: Storage of Spatial Information by the Maintenance Mechanism of LTP. In: Science . 313, 2006, pp. 1141-1144. doi: 10.1126 / science.1128657
- ↑ TC Sacktor: How does PKMzeta maintain long-term memory? In: Nat. Rev. Neurosci. 12, 2011, pp. 9-15. doi: 10.1038 / nrn2949
- ↑ Deutschlandradio Forschung aktuell, broadcast on March 4, 2011