POU family

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The POU family is a group of transcription factors with a highly conserved homeodomain .

15 POU genes were found in the human genome . In contrast, the genome of the model organisms Drosophila and Caenorhabditis elegans has only five and four POU genes, respectively. Nevertheless, these transcription factors regulate a large number of biological processes. This is possible through a wide range of interactions with other transcription or cofactors . The interacting proteins can also come from the POU family or from other families such as Pax or Sox .

Naming

The acronym POU is derived from three transcription factors present in many living things:

  • the letter P comes from the pituitary-specific transcription factor Pit-1 (= POU1F1),
  • the O of the octamer transcription factors Oct-1 (= POU2F1) and Oct-2 (= POU2F2), where the octamer sequence is ATGCAAAT, and
  • the letter U from the Unc-86 neural transcription factor of Caenorhabditis elegans

Occurrence according to Art

The POU gene domain was found in a wide variety of living beings, such as Caenorhabditis elegans , Drosophila , the clawed frogs ( Xenopus ), the zebrafish and humans; in plants and fungi, however, not so far.

Transcription factors of the POU family (human)

The human genome comprises 15 genes that are assigned to the POU family (in brackets the alternative or outdated gene designation):

Individual evidence

  1. ↑ HR Schöler: Trophoblast gene expression and function of genes in the germ line of the mouse. In: Activity report of the Max Planck Society 2004, pp. 87–93.
  2. ↑ Genenames.org: POU1F1 accessed November 29, 2008
  3. ↑ Genenames.org: POU2F1 accessed November 29, 2008
  4. ↑ Genenames.org: POU2F2 accessed November 29, 2008
  5. ↑ Genenames.org: POU2F3 accessed November 29, 2008
  6. ↑ Genenames.org: POU3F1 accessed November 29, 2008
  7. ↑ Genenames.org: POU3F2 accessed November 29, 2008
  8. ↑ Genenames.org: POU3F3 accessed November 29, 2008
  9. ↑ Genenames.org: POU3F4 accessed November 29, 2008
  10. ↑ Genenames.org: POU4F1 accessed on November 29, 2008
  11. ↑ Genenames.org: POU4F2 accessed on November 29, 2008
  12. ↑ Genenames.org: POU4F3 accessed on November 29, 2008
  13. ↑ Genenames.org: POU5F1 accessed November 29, 2008
  14. ↑ Genenames.org: POU6F1 accessed November 29, 2008
  15. ↑ Genenames.org: POU6F2 accessed November 29, 2008

literature

  • K. Phillips and B. Luisi: The virtuoso of versatility: POU proteins that flex to fit. In: J. Mol. Biol. 302, 2000, pp. 1023-1039. PMID 11183772
  • H. Niwa et al .: Platypus Pou5f1 reveals the first steps in the evolution of trophectoderm differentiation and pluripotency in mammals. In: Evol Dev. 10, 2008, pp. 671-682. PMID 19021737
  • L. Samady et al: The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. In: Int J Cancer 118, 2006, pp. 869-878. PMID 16152597
  • D. Ndisang et al .: Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a. In: Oncogene 25, 2006, pp. 51-60. PMID 16247485
  • R. Catena et al .: Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells. In: J Biol Chem 279, 2004, pp. 41846-41857. PMID 15262984
  • M. Ilia; Oct-6 transcription factor. In: Int Rev Neurobiol 59, 2004, S, 471-489. PMID 15006499