PSD-95
| PSD-95 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 724 amino acids | |
| Secondary to quaternary structure | Lipoprotein | |
| Isoforms | 2 | |
| Identifier | ||
| Gene name | DLG4 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | multicellular animals | |
PSD-95 (of English. Postsynaptic density protein 95 ), and SAP-90 ( synapse-associated protein 90 ), is a protein from the group of membrane-associated guanylate - kinases ( MAGUK ), and is encoded by the gene DLG4. PSD-93 , NMDA receptors and special potassium channels can form protein complexes with PSD-95 . PSD-93 and PSD-95 both interact in postsynaptic locations to create a multimeric framework for the assembly of receptors, ion channels, and associated signaling proteins to build.
PSD-95 is the best studied DLG protein. Like all MAGUK proteins, PSD-95 contains three PDZ domains , an SH3 domain and a guanylate kinase-like domain (GK) in its structure . It is found almost exclusively in the postsynaptic density ( PSD ) of neurons , from which the name PSD-95 is derived. Possible binding partners are, in addition to NMDA receptors and potassium channels, also neuroligin and AMPA receptors . PSD-95 plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation .
Individual evidence
- ↑ InterPro : IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal (English)
- ^ GeneID 1742
- ↑ Zhen Xin Mahoney: Discs-large homolog 1 (DLG1) and laminins in mouse tissue morphogenesis and maintenance , Washington University in St. Louis, ProQuest, 2007, ISBN 0-549-46561-8 , p. 33.
- ^ Pre- and postsynaptic membranes. Literature seminar introduction to neurochemistry at the FU Berlin , SS 2000.
- ↑ UniProt P78352
- ^ D. Meyer, Bonhoeffer T., and Scheuss V .: Balance and Stability of Synaptic Structures during Synaptic Plasticity . In: Neuron . 82, No. 2, 2014, pp. 430–443. doi : 10.1016 / j.neuron.2014.02.031 . PMID 24742464 .