Paraneoplastic pemphigus
| Classification according to ICD-10 | |
|---|---|
| L10 | Pemphigus diseases |
| C80 | Malignant neoplasm without specifying the location |
| ICD-10 online (WHO version 2019) | |
The paraneoplastic pemphigus is as much as the erythema gyratum repens , erythema migrans necrotizing , hypertrichosis lanuginosa acquisita and acanthosis nigricans to the obligatory paraneoplasia . This blistering disease is almost always associated with a tumor. In some of the cases is for the occurrence of paraneoplastic pemphigus of Castleman's disease is based.
Tumor diseases associated with paraneoplastic pemphigus:
- Non-Hodgkin lymphomas , such as CLL
- undifferentiated sarcomas
- Thymoma
In the histology to find Akantholysen and dyskeratosis . There is accumulation of immunoglobulins on the basement membrane with antibodies against desmoplactin I and II, BP antigen , desmoglein and others.
Appearance
The lesions of paraneoplastic pemphigus do not correspond to the “classic” pemphigus vulgaris , but are polymorphic. The clinical picture offers a mixture of pemphigus vulgaris and erythema exudativum multiforme . The skin but also the mucous membranes and the oral cavity can be affected.
literature
- Peter Fritsch: Dermatology, Venereology. Basics, clinic, atlas. 2nd Edition. Springer, Berlin et al. 2004, ISBN 3-540-00332-0 .
- Constantin E. Orfanos, Claus Garbe: Therapy of skin diseases. Including allergology, andrology, phlebology, proctology, trichology, pediatric dermatology, tropical dermatosis, venereology, and HIV infection, and dermatological emergencies. 2nd, completely revised and expanded edition. Springer, Berlin et al. 2002, ISBN 3-540-41366-9 , p. 475.
Individual evidence
- ↑ Alexander Meves: Dermatology intensive course. Elsevier, Urban and Fischer, Munich et al. 2003, ISBN 3-437-41162-4 , p. 266.
