Pendrin
| Pendrin | ||
|---|---|---|
| Mass / length primary structure | 85.7 kilodaltons / 780 amino acids (isoform 1)
39.3 kilodaltons / 349 amino acids (isoform 2) |
|
| Isoforms | 2 | |
| Identifier | ||
| Gene name (s) | SLC26A4 DFNB4, EVA, PDS, TDH2B | |
| External IDs | ||
Pendrin a is ion channel , the apical in thyrocytes located and by the sodium-iodide symporter recorded iodide in the colloidal space of Schilddrüsenfollikels passes. Pendrin can also be detected in the proximal part of Henle's loop of the nephron. Here it exchanges chloride ions for formate in the antiport on the luminal membrane. Thus it plays a decisive role in the transmembrane chloride absorption.
In addition to iodide, Pendrin can also transport sulfate and chloride .
literature
- Stefan Silbernagl / Hans - Christian Pape / Armin Kurz: Physiology . 7th edition. Georg Thieme Verlag, p. 399 .
- Löffler / Petrides: Biochemistry and Pathobiochemistry . 9th edition. Springer-Verlag, Berlin 2014, ISBN 978-3-642-17972-3 , pp. 516 .