PentraSorb

PentraSorb is a medical product for extracorporeal use, which is used in a procedure similar to dialysis - more precisely apheresis - to filter the C-reactive protein (CRP) from the blood plasma of patients. It is an approved process and is produced by the Brandenburg company Pentracor in Hennigsdorf near Berlin .

Areas of application

An increased level of CRP in the blood is suspected of causing significantly more severe damage to the affected organs in heart attacks , strokes , moderate and severe courses of COVID-19 as well as chronic inflammatory bowel diseases such as Crohn's disease or ulcerative colitis and other inflammatory diseases such as rheumatism to care. Studies are currently running (as of June 2020) on the following indications :

A study in heart attack patients has already been completed and another case report appears to confirm the effectiveness of the treatment.

functionality

The PentraSorb CRP adsorber is a plastic housing filled with a CRP-binding ligand . This is connected to a device which pumps the blood plasma through the adsorber in certain cycles. In the adsorber, the ligand ensures a reduction in CRP and is therefore intended, for example, to inhibit the formation of scar tissue after a heart attack. In the event of an acute myocardial infarction, treatment must be initiated within 48 hours of the vascular occlusion, as the concentration of C-reactive protein in the blood is highest during this period.

Individual evidence

↑ Home. Accessed June 9, 2020 (German).
↑ rbb PRAXIS: Blood washing against Sars-CoV-2? | ARD media library. Retrieved June 9, 2020 .
↑ Qiurong Ruan, Kun Yang, Wenxia Wang, Lingyu Jiang, Jianxin Song: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China . In: Intensive Care Medicine . tape 46 , no. 5 , March 3, 2020, ISSN 1432-1238 , p. 846–848 , doi : 10.1007 / s00134-020-05991-x , PMID 32125452 , PMC 7080116 (free full text).
↑ Darko Boljevic, Aleksandra Nikolic, Sinisa Rusovic, Jovana Lakcevic, Milovan Bojic: A Promising Innovative Treatment for ST-Elevation Myocardial Infarction: The Use of C-Reactive Protein Selective Apheresis: Case Report . In: Blood Purification . February 28, 2020, ISSN 0253-5068 , p. 1-5 , doi : 10.1159 / 000506176 , PMID 32114573 ( karger.com [accessed June 9, 2020]).
↑ DRKS - German Clinical Trials Register. Retrieved June 9, 2020 .
↑ Possible uses. In: Pentracor. Accessed June 9, 2020 (German).
↑ Medicom | CRP apheresis: a new treatment option for inflammation. Retrieved June 12, 2020 .

[1] Home. Accessed June 9, 2020 (German).

[2] rbb PRAXIS: Blood washing against Sars-CoV-2? | ARD media library. Retrieved June 9, 2020 .

[3] Qiurong Ruan, Kun Yang, Wenxia Wang, Lingyu Jiang, Jianxin Song: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China . In: Intensive Care Medicine . tape 46 , no. 5 , March 3, 2020, ISSN 1432-1238 , p. 846–848 , doi : 10.1007 / s00134-020-05991-x , PMID 32125452 , PMC 7080116 (free full text).

[4] Darko Boljevic, Aleksandra Nikolic, Sinisa Rusovic, Jovana Lakcevic, Milovan Bojic: A Promising Innovative Treatment for ST-Elevation Myocardial Infarction: The Use of C-Reactive Protein Selective Apheresis: Case Report . In: Blood Purification . February 28, 2020, ISSN 0253-5068 , p. 1-5 , doi : 10.1159 / 000506176 , PMID 32114573 ( karger.com [accessed June 9, 2020]).

[5] DRKS - German Clinical Trials Register. Retrieved June 9, 2020 .

[6] Possible uses. In: Pentracor. Accessed June 9, 2020 (German).

[7] Medicom | CRP apheresis: a new treatment option for inflammation. Retrieved June 12, 2020 .