Colloidal solution for infusion
Colloidal infusion solutions are preparations used in infusion therapy that stabilize or increase the volume in the blood vessels . They contain colloidal macromolecules such as carbohydrates ( hydroxyethyl starch , dextrans ) or proteins ( gelatin or human albumin ). Since these cannot cross the vessel wall, the colloid-osmotic pressure they increase is maintained until the molecules are eliminated by enzymatic degradation or absorption by the mononuclear phagocytosis system . This has a pronounced effect on the blood volume, which is why they are used to compensate for greater volume losses in hypovolemic shock . The improvement in the microcirculation caused by the colloids also has a positive effect in the shock.
Depending on the preparation, the solutions behave hypo- to iso-oncotic (lower or equal colloid osmotic pressure) compared to blood plasma ( plasma substitute ) or hyperoncotic (higher colloid osmotic pressure, plasma expanders ). The hyperoncotic effect pulls water from the extracellular space into the bloodstream and thus counteracts any loss of volume.
possible side effects
Possible side effects are changes in blood clotting (tendency to bleed), anaphylactic reactions and acute kidney failure . Human albumin also carries the risk of transmitting viral infections.
literature
- Rossaint, Werner, Zwissler (ed.): The anesthesiology. General and special anesthesiology, pain therapy and intensive care medicine. Springer, Berlin; 2nd edition 2008. ISBN 978-3-540-76301-7
- Zander: fluid therapy. (2nd extended edition) Bibliomed 2009. ISBN 3-89556-040-5 ( PDF, 892 kB ( Memento of July 5, 2011 in the Internet Archive ))
