Pseudogout

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Classification according to ICD-10
M11.1 Familial chondrocalcinosis
M11.2 Other chondrocalcinosis
- chondrocalcinosis nos
ICD-10 online (WHO version 2019)

Under pseudogout (also chondrocalcinosis ) refers to a gout-like disease of the joints , but a fundamentally different pathogenetic mechanism has. While in the gout rather urate crystals play a role in pseudogout is calcium pyrophosphate for the degeneration of the cartilage responsible.

The differential diagnosis of gout is often simple, as pseudogout mainly affects large joints (often the knee first ), while gout usually affects the metatarsophalangeal joint first (then called podagra ). An increase in density in the cartilage can be demonstrated radiologically . Calcification of the disc in the hands is typical, but evidence of calcium pyrophosphate in the joint effusion is evidence . Arthroscopic specimens may show rhomboid-shaped crystals.

A distinction is made between primary and secondary chondrocalcinosis. Hereditary defects in the metabolism of pyrophosphate are discussed in the primary form. Secondary causes may occur a. in connection with gout , hyperparathyroidism , hypothyroidism , hemochromatosis , Wilson's disease , rheumatoid arthritis or after trauma .

Therapeutic anti-inflammatory (is anti-inflammatory ) acute treatment indicated to relieve the pain, while the cause search is advancing.

Predisposing diseases are, in addition to joint-related changes such as misalignment, infection, metabolic diseases:

  • Hyperparathyroidism
  • Familial hypercalcemic hypocalciuria
  • Hemochromatosis
  • Hypothyroidism
  • Hypomagnesaemia
  • Hypophosphatasia
  • gout
  • Hepatolenticular degeneration
  • Ochronosis

Web links

Individual evidence

  1. ↑ a b W. Pschyrembel: Clinical Dictionary . 265th edition. Verlag Walter de Gruyter, 2014, ISBN 3-11-018534-2 .
  2. ↑ Rheumatology checklist . 2nd Edition. Thieme Verlag, Stuttgart 2000, p. 297.