Pseudohypertrophy
In medicine, pseudohypertrophy is an enlargement of the organs due to the increase in interstitial connective tissue . The connective tissue that lies within the organs between the parenchymal cells , i.e. the organ-specific cells, is referred to as interstitial . The pseudohypertrophy is differentiated from the hypertrophy , in which there is an enlargement of the organs by enlarging the parenchymal cells.
Muscle pseudohypertrophy
In myology (muscle theory), pseudohypertrophy refers to an increase in muscle volume due to fat tissue storage or connective tissue remodeling of the muscles . The increase in size of the muscle does not result from an enlargement of the muscle cells, as is the case with hypertrophy .
Pseudohypertrophy is typical, for example, in the Becker-Kiener and Duchenne muscular dystrophies . In these diseases, pseudohypertrophy is particularly pronounced in the area of the calves (so-called gnome calves). Even with the Myotilinopathie and some limb-girdle muscular dystrophy (z. B. LGMD2A , LGMD2C , LGMD2D and LGMD2F ) is a pseudohypertrophy typical. In diseases with neurogenic changes in the muscles, i.e. in diseases in which the innervation of the muscles is disturbed, pseudohypertrophy can also occur. A classic example is the Kugelberg-Welander spinal muscular atrophy , which, as with the muscular dystrophies mentioned above, primarily affects the calves. Pseudohypertrophies also occur in the heart muscle, for example in some cardiomyopathies and after a heart attack .
Whether it is a pseudohypertrophy or a "real" hypertrophy can be determined by means of computed tomography , magnetic resonance imaging , ultrasound and especially by microscopic examination of muscle tissue after muscle biopsy .
literature
- Peter P. Urban : Clinical-neurological examination techniques Thieme Verlag , 2012, ISBN 978-3131599018 , page 223
Individual evidence
- ↑ Christian P. Speer , Manfred Gahr : Pädiatrie Springer Verlag , 2009, ISBN 978-3540694793 , page 292
