Pseudohypertrophy
In medicine, pseudohypertrophy is an enlargement of the organs due to the increase in interstitial connective tissue . The connective tissue that lies within the organs between the parenchymal cells , i.e. the organ-specific cells, is referred to as interstitial . The pseudohypertrophy is differentiated from the hypertrophy , in which there is an enlargement of the organs by enlarging the parenchymal cells.
Muscle pseudohypertrophy
![](https://upload.wikimedia.org/wikipedia/commons/thumb/4/49/Duchenne-muscular-dystrophy.jpg/220px-Duchenne-muscular-dystrophy.jpg)
In myology (muscle theory), pseudohypertrophy refers to an increase in muscle volume due to fat tissue storage or connective tissue remodeling of the muscles . The increase in size of the muscle does not result from an enlargement of the muscle cells, as is the case with hypertrophy .
Pseudohypertrophy is typical, for example, in the Becker-Kiener and Duchenne muscular dystrophies . In these diseases, pseudohypertrophy is particularly pronounced in the area of the calves (so-called gnome calves). Even with the Myotilinopathie and some limb-girdle muscular dystrophy (z. B. LGMD2A , LGMD2C , LGMD2D and LGMD2F ) is a pseudohypertrophy typical. In diseases with neurogenic changes in the muscles, i.e. in diseases in which the innervation of the muscles is disturbed, pseudohypertrophy can also occur. A classic example is the Kugelberg-Welander spinal muscular atrophy , which, as with the muscular dystrophies mentioned above, primarily affects the calves. Pseudohypertrophies also occur in the heart muscle, for example in some cardiomyopathies and after a heart attack .
Whether it is a pseudohypertrophy or a "real" hypertrophy can be determined by means of computed tomography , magnetic resonance imaging , ultrasound and especially by microscopic examination of muscle tissue after muscle biopsy .
literature
- Peter P. Urban : Clinical-neurological examination techniques Thieme Verlag , 2012, ISBN 978-3131599018 , page 223
Individual evidence
- ↑ Christian P. Speer , Manfred Gahr : Pädiatrie Springer Verlag , 2009, ISBN 978-3540694793 , page 292