Purinergic receptor

from Wikipedia, the free encyclopedia

Purinergic receptors , also purinoceptors called, are a family of proteins and receptors of the cell surface , which occur in nearly all mammalian tissues. In the field of purinergic signal transmission , these receptors are involved in learning and memory processes, movement and eating behavior, and sleep. In particular, they are involved in several cellular functions, including cell proliferation and neural stem cell migration , vascular reactivity, apoptosis, and cytokine secretion. These functions have not been well characterized, and the effect of the extracellular microenvironment on their function is also poorly understood.

The term purinergic receptor was originally introduced to illustrate certain classes of membrane receptors that mediate the relaxation of intestinal smooth muscle in response to the release of ATP (P2 receptors) or adenosine (P1 receptors). P2 receptors have been further divided into five subclasses: P2X, P2Y, P2Z, P2U, and P2T. To further differentiate P2 receptors, the subclasses were divided into families of metabotropic (P2Y, P2U, and P2T) and ionotropic receptors (P2X and P2Z).

In 2014, the first purinergic receptor in plants, DORN1, was discovered.

Individual evidence

  1. ^ R. Alan North: Molecular Physiology of P2X Receptors . In: Physiological Reviews . tape 82 , no. 4 , January 10, 2002, ISSN  0031-9333 , p. 1013-1067 , doi : 10.1152 / physrev.00015.2002 .
  2. ↑ a b Geoffrey Burn floor: Introduction to Purinergic Signaling in the Brain . In: Glioma Signaling (=  Advances in Experimental Medicine and Biology ). Springer Netherlands, Dordrecht 2013, ISBN 978-94-007-4719-7 , pp. 1–12 , doi : 10.1007 / 978-94-007-4719-7_1 .
  3. ^ Henning Ulrich, Maria P. Abbracchio, Geoffrey Burnstock: Extrinsic Purinergic Regulation of Neural Stem / Progenitor Cells: Implications for CNS Development and Repair . In: Stem Cell Reviews and Reports . tape 8 , no. 3 , September 1, 2012, ISSN  1558-6804 , p. 755-767 , doi : 10.1007 / s12015-012-9372-9 .
  4. ↑ Yangrong Cao, Kiwamu Tanaka, Cuong T Nguyen, Gary Stacey: Extracellular ATP is a central signaling molecule in plant stress responses . In: Current Opinion in Plant Biology (=  SI: Biotic interactions ). tape 20 , August 1, 2014, ISSN  1369-5266 , p. 82–87 , doi : 10.1016 / j.pbi.2014.04.009 ( sciencedirect.com [accessed January 1, 2020]).