Rho guanine nucleotide exchange factor 2

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Rho guanine nucleotide exchange factor 2
other names
  • Guanine Nucleotide Exchange Factor H1
  • GEF-H1
  • Microtubule-Regulated Rho-GEF
  • Proliferating Cell Nucleolar Antigen p40
  • Rho / Rac Guanine Nucleotide Exchange Factor (GEF) 2
  • KIAA0651
  • LFP40
Properties of human protein
Mass / length primary structure 986 amino acids, 111543 Da
Identifier
Gene names ARHGEF2 KIAA0651, LFP40
External IDs
Orthologue
human House mouse
Entrez 9181 16800
Ensemble ENSG00000116584 ENSMUSG00000028059
UniProt Q92974 Q60875
Refseq (mRNA) NM_001162383 NM_001198911
Refseq (protein) NP_001155855 NP_001185840
Gene locus Chr 1: 155.95 - 156.01 Mb Chr 3: 88.61 - 88.65 Mb
PubMed search 9181 16800

The Rho-guanine nucleotide exchange factor 2 is a protein prepared by the gene ARHGEF2 is encoded. It plays an important role in many cellular processes that are triggered by extracellular stimuli via G-protein-coupled receptors . The protein activates Rho-GTPase by helping to exchange GDP for GTP . It interacts with PAK1 .

Individual evidence

  1. ↑ a b UniProt Q92974
  2. ↑ ARHGEF2 Rho / Rac guanine nucleotide exchange factor (GEF) 2 [Homo sapiens (human) ]