Ribose-1-phosphate

Structural formula
α- anomer of D- ribose-1-phosphate ( pyranose form ) under physiological conditions
General
Surname	Ribose-1-phosphate
other names	Rib-1-P
Molecular formula	C 5 H 11 O 8 P
External identifiers / databases
CAS number 14075-00-4 58459-37-3 (cyclohexylammonium salt) PubChem 439236 DrugBank DB03101 Wikidata Q18213356
properties
Molar mass	230.02 g mol −1
safety instructions
GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Ribose-1-phosphate is a phosphoric acid ester of ribose and the isomer of ribose-5-phosphate . It is an intermediate in the breakdown of nucleosides . Physiologically, only the D isomer plays a role.

Reactions

α- D- ribose-1-phosphate can be formed alternately from D- ribose-5-phosphate by a phosphopentomutase ( EC  5.4.2.7 ) , according to:

${\displaystyle {\text{Ribose-5-phosphat}}\rightleftharpoons {\text{Ribose-1-phosphat}}}$

In this conversion, α- D - ribose-1,5-bisphosphate , α- D - 2-deoxyribose-1,5-bisphosphate or α- D - glucose-1,6-bisphosphate serve as cofactors .

Alternatively, Rib-1-P is formed during the breakdown of nucleosides , which catalyzes a purine nucleoside phosphorylase or a pyrimidine nucleoside phosphorylase ( EC  2.4.2.2 ) or a uridine phosphorylase ( EC  2.4.2.3 ):

${\displaystyle {\text{Nucleosid}}+{\text{P}}_{i}\longrightarrow {\text{Nukleinbase}}+{\text{Ribose-1-phosphat}}}$

literature

• Maria G. Tozzi, Marcella Camici, Laura Mascia, Francesco Sgarrella, Piero L. Ipata: Pentose phosphates in nucleoside interconversion and catabolism . In: FEBS Journal . tape 273 , no. 6 , March 2006, p. 1089–1101 , doi : 10.1111 / j.1742-4658.2006.05155.x , PMID 16519676 (free full text access ).

Web links

Wikibooks: Biochemistry and pathobiochemistry: alpha-D-ribose-1-phosphate  - learning and teaching materials

Individual evidence

1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.