Rubeosis iridis

Classification according to ICD-10
H21.1	Other vascular diseases of the iris and ciliary body - neovascularization of the iris or ciliary body - rubeosis iridis
ICD-10 online (WHO version 2019)

The rubeosis iridis or rubeosis diabetic is a pronounced filling of the iris vessels or increased vessel formation ( neovascularization ) in the iris and in the chamber of the eye , or more precisely the angle chamber, Angulus iridocornealis with pink red color "rubeosis" the iris.

The first description comes from the year 1928 for diabetics by the Austrian ophthalmologist Robert Salus.

root cause

A lack of oxygen in the retina due to diabetic retinopathy (most common cause), retinal vascular occlusion ( retinal artery occlusion , central vein thrombosis ) or retinal detachment leads to the formation of new vessels in the iris and chamber angles via the vascular endothelial growth factor .

The causes can be divided into:

Vascular diseases of large neighboring vessels such as the carotid artery flow area

Vascular diseases of the eye

Diseases of the retina such as the consequences of Eales disease or sickle cell retinopathy

Iris tumors
after the inflammation has passed

classification

Clinically, a distinction can be made between:

Focal, stationary type due to direct trauma , favorable prognosis
Diffuse, progressive type due to vascular processes, irreversible, unfavorable prognosis

Differential diagnosis

The “pseudo-rubeosis-iridis” is to be differentiated due to an atrophy of the connective tissue of the iris with better visibility of the iris vessels.

treatment

The treatment is geared towards the underlying disease; drug-based inhibition of the formation of new blood vessels has not yet been established.

literature

M. Niestrata-Ortiz, JP Li, N. Davies: Rubeosis iridis in patients with diabetes: not forgetting oculoischaemic syndrome as a differential. In: BMJ Case Reports. Bd. 2014, November 2014, S., doi: 10.1136 / bcr-2014-207236 , PMID 25404252 , PMC 4244368 (free full text).
S. Gartner, P. Henkind: Neovascularization of the iris (rubeosis iridis). In: Survey of ophthalmology. Vol. 22, No. 5, 1978 Mar-Apr, pp. 291-312, PMID 349748 (Review).

Individual evidence

↑ Richard Daikeler, idols Use, Sylke Waibel: diabetes. Evidence-based diagnosis and therapy. 10th edition. Kitteltaschenbuch, Sinsheim 2015, ISBN 978-3-00-050903-2 , p. 21.
^ Willibald Pschyrembel : Clinical Dictionary , 266th, updated edition, de Gruyter, Berlin 2014, ISBN 978-3-11-033997-0
↑ ^a ^b ^c Entry on Rubeosis_iridis in Flexikon , a wiki of the DocCheck company

↑ ^a ^b ^c ^d Rubeosis iridis (neovascularization on the iris)> KW Ruprecht: [Rubeosis iridis (neovascularization on the iris)]. In: Clinical monthly sheets for ophthalmology. Vol. 222, No. 4, April 2005, p. 342, doi: 10.1055 / s-2005-858081 , PMID 15844046 .

↑ Salus R: Rubeosis iridis diabetica, an unknown diabetic change in the iris. In: Medical Clinic Vol. 24, 1928, pp. 256-258

[1] Richard Daikeler, idols Use, Sylke Waibel: diabetes. Evidence-based diagnosis and therapy. 10th edition. Kitteltaschenbuch, Sinsheim 2015, ISBN 978-3-00-050903-2 , p. 21.

[2] Willibald Pschyrembel : Clinical Dictionary , 266th, updated edition, de Gruyter, Berlin 2014, ISBN 978-3-11-033997-0

[flexikon-3] Entry on Rubeosis_iridis in Flexikon , a wiki of the DocCheck company

[Ruprecht-4] Rubeosis iridis (neovascularization on the iris)> KW Ruprecht: [Rubeosis iridis (neovascularization on the iris)]. In: Clinical monthly sheets for ophthalmology. Vol. 222, No. 4, April 2005, p. 342, doi: 10.1055 / s-2005-858081 , PMID 15844046 .

[5] Salus R: Rubeosis iridis diabetica, an unknown diabetic change in the iris. In: Medical Clinic Vol. 24, 1928, pp. 256-258