Rudolf Geyer (chemist)

Rudolf Geyer

Rudolf Geyer (born March 31, 1947 in Gotha / Thuringia ) is a German chemist and glycobiologist .

Life

After fleeing to the Federal Republic of Germany (1958), Rudolf Geyer attended the König-Heinrich-Schule in Fritzlar, where he obtained his university entrance qualification in 1966. From 1968 to 1973 he studied chemistry in Darmstadt and Freiburg. He then carried out his dissertation on “Proteins of the outer membrane of Gram-negative bacteria; Isolation and characterization of a protein from Salmonella with an affinity for lipopolysaccharide ”at the Max Planck Institute for Immunology in Freiburg and was awarded a Dr. rer. nat. PhD. From 1978 to 1990 Rudolf Geyer was a research assistant / university assistant and headed his own working group at the biochemical institute of the medical department of the Justus Liebig University in Giessen. In 1983 he did a research stay at the Memorial Sloan Kettering Cancer Center in New York in the group of Alan Oliff. In 1986 he submitted his habilitation thesis on the subject of “Structural analyzes of the carbohydrate content of glycoproteins of murine leukemia viruses and other glycoconjugates” and in 1987 received the Venia Legendi for biochemistry at the University of Giessen. Since 1990 Rudolf Geyer worked there as a professor of biochemistry. In addition, he was managing director of the Biochemical Institute from 1996 to 1999. Rudolf Geyer retired on March 31, 2012 . Rudolf Geyer is married and has two daughters.

Act

The scientific work of Rudolf Geyer concentrated on the structural analysis of glycoconjugates as well as the targeted (further) development of analytical methods. The biological diversity as well as the importance of structures characterized in this way becomes clear through his function as sub-project leader in the following Collaborative Research Centers (SFB) and in the graduate college (both DFG- funded):

• 1986–1988 Subproject leader SFB 47: "Pathogenicity mechanisms of viruses at the molecular and cellular level as well as in the organism" (Subproject A6)
• 1989–1996 Subproject leader SFB 272: "Molecular Basics of Cell Biological Switching Processes" (Subprojects B1 and Z2)
• 1992–2002 sub-project leader in the graduate college "Molecular Biology and Pharmacology"
• 1997–2008 Subproject leader SFB 535: "Invasion Mechanisms and Replication Strategies of Pathogens" (Subprojects A8, A15, Z1)

In addition, Rudolf Geyer worked on the editorial boards of the following magazines:

• 1986-1995 Biomedical Chromatography
• 1996-2010 Glycobiology
• 1998-2005 Biochimica et Biophysica Acta
• 2004-2006 Journal of Biochemistry

From 1994 to 2000 he was an Invited Teacher at the biennial FEBS Advanced Course on Glycoconjugates: Structural and Functional Glycobiology in Lille / France and between 2006 and 2010 he was an Invited Teacher at the 9th to 11th “Summer Course Glycoscience” “In Wageningen / Netherlands. In October 2000 Rudolf Geyer was an Invited Lecturer at the Institute of S. Hase, Department of Chemistry, University of Osaka in Japan.

Awards

In 1996 Rudolf Geyer received the Ludwig Schunk Prize for Human Medicine from the University of Giessen.

Honorary positions and functions

• 1994–2005 member of the funding committee of the Faculty of Medicine at the University of Giessen
• 1996–2003 member of the faculty council of the Faculty of Medicine at the University of Giessen
• 1998–2006 member of the Schunk Prize Commission of the Medical Faculty of the University of Giessen
• 2001–2006 member of the jury for the Friedrich Dost Prize of the Medical Society
• 2004–2006 speaker of the study group "Glycobiology" of the German Society for Biochemistry and Molecular Biology (GBM)
• 2004–2006 Member of the Expert Commission "Structural Medicine" of the European Science Foundation (ESF)
• 2005–2009 member of the EU research network "EUROCarbDB"
• 2006–2009 Dean of Studies of the Faculty of Medicine at the University of Giessen
• 2008–2011 Chairman of the "Glycoanalysis Core" of the "EuroGlycoscience Forum"

Publications (selection)

• K. Kuroda, H. Geyer, R. Geyer, W. Doerfler, H.-D. Klenk (1990): The oligosaccharides of influenza virus hemagglutinin expressed in insect cells by a baculovirus vector. Virology, 174: 418-29. doi : 10.1016 / 0042-6822 (90) 90095-9
• Y.Wada, P. Azadi, CE Costello, A. Dell, RA Dwek, H. Geyer, R. Geyer, K. Kakehi, NG Karlsson, K. Kato, N. Kawasaki, K.-H. Khoo, S. Kim, A. Kondo, E. Lattova, Y. Mechref, E. Miyoshi, K. Nakamura, H. Narimatsu, MV Novotny, NH Packer, H. Perreault, J. Peter-Katalinić, G. Pohlentz, VN Reinhold, PM Rudd, A. Suzuki, N. Taniguchi (2007): Comparison of the methods for profiling glycoprotein glycans — HUPO Human Disease Glycomics / Proteome Initiative multi-institutional study. Glycobiology, 411-22. doi : 10.1093 / glycob / cwl086
• A. Ceroni, K. Maass, H. Geyer, R. Geyer, A. Dell, SM Haslam (2008). GlycoWorkbench: A Tool for the Computer-Assisted Annotation of Mass Spectra of Glycans. J. Proteome Res, 7: 1650-9. doi : 10.1021 / pr7008252
• R. Geyer, H. Geyer, S. Kühnhardt, W. Mink, S. Stirm (1983). Methylation analysis of complex carbohydrates in small amounts: Capillary gas chromatography-mass fragmentography of methylalditol acetates obtained from N-glycosidically linked glycoprotein oligosaccharides. Anal. Biochem. , 133: 197-207. doi : 10.1016 / 0003-2697 (83) 90243-9
• H. Geyer, R. Geyer (2006). Strategies for analysis of glycoprotein glycosylation. Biochim. Biophys. Acta , 1764: 1853-69. doi : 10.1016 / j.bbapap.2006.10.007
• R. Geyer, H. Geyer (1994). Saccharide linkage analysis using methylation and other techniques. Methods Enzymol, 230: 86-108. doi : 10.1016 / 0076-6879 (94) 30009-7
• T. Yamashita, Y.-P. Wu, R. Sandhoff, N. Werth, H. Mizukami, JM Ellis, JL Dupree, R. Geyer, K. Sandhoff, RL Proia (2005). Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. Proc. Natl. Acad. Sci. USA , 102: 2725-30. doi : 10.1073 / pnas.0407785102
• R. Geyer, H. Geyer, S. Kühnhardt, W. Mink, S. Stirm (1982). Capillary gas chromatography of methylhexitol acetates obtained upon methylation of N-glycosidically linked glycoprotein oligosaccharides. Anal Biochem, 121: 263-74. doi : 10.1016 / 0003-2697 (82) 90478-X
• R. Geyer, H. Geyer; S. Stirm, G. Hunsmann, J. Schneider, U. Dabrowski, J. Dabrowski (1984). Major oligosaccharides in the glycoprotein of Friend murine leukemia virus: structure elucidation by one- and two-dimensional proton nuclear magnetic resonance and methylation analysis. Biochemistry , 23: 5628-37. PMID 6439245 .
• H. Geyer, S. Schmitt, M. Wuhrer, R. Geyer (1999). Structural analysis of glycoconjugates by on-target enzymatic digestion and MALDI-TOF-MS. Anal. Chem. 71: 476-82. doi : 10.1021 / ac980712w