Serum response factor
| Serum response factor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 508 amino acids | |
| Secondary to quaternary structure | Heterodimer | |
| Identifier | ||
| Gene name | SRF | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Vertebrates | |
The serum response factor (SRF) is a protein that has a gene regulatory effect in vertebrates, i.e. it switches genes on or off. SRF is induced via signal cascades , whereupon it influences the gene expression of its target genes. The target genes include so-called Immediate Early Genes (IEGs), which are expressed very quickly by SRF, but also actin, a component of the cytoskeleton , for example .
SRF binds the DNA as a homo dimer to a CArG box in the regulatory region of the target gene.
SRF can also regulate genes together with ternary complexing agents ( e.g. Elk-1).
Individual evidence
- ↑ Homologues at OMA
- ^ G. Posern, R. Treisman: Actin 'together: serum response factor, its cofactors and the link to signal transduction. In: Trends in cell biology. Volume 16, Number 11, November 2006, pp. 588-596, ISSN 1879-3088 . doi : 10.1016 / j.tcb.2006.09.008 . PMID 17035020 .
- ↑ JM Miano: Role of serum response factor in the pathogenesis of disease. In: Laboratory investigation; a journal of technical methods and pathology. Volume 90, Number 9, September 2010, pp. 1274-1284, ISSN 1530-0307 . doi : 10.1038 / labinvest.2010.104 . PMID 20498652 .