Sorbitan sesquioleate

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Structural formula
No drawing available
General
Surname Sorbitan sesquioleate
other names
  • SORBITAN SESQUIOLEATE ( INCI )
  • 2- (3,4-Dihydroxyoxolan-2-yl) ethane-1,2-diol-mono / bis - [(9 Z ) -octadec-9-enoate]
  • Span 83 (brand name)
Molecular formula C 33 H 60 O 6.5 (empirical)
External identifiers / databases
CAS number 8007-43-0
EC number 232-360-1
ECHA InfoCard 100.029.416
PubChem 6433515
Wikidata Q27231186
properties
Molar mass Variable
solubility

Dispersible in water, soluble in fatty oils, sparingly soluble in anhydrous ethanol

safety instructions
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sorbitan sesquioleate is a mixture of sorbitan fatty acid esters that is obtained by esterifying formally 2 moles of sorbitol and / or its mono- and dianhydrides ( sorbitan , isosorbide ) with 3 moles of oleic acid .

use

Sorbitan sesquioleate is used as a dispersant or emulsifier in human and veterinary medicinal products and in cosmetics as well as in other technical applications.

properties

Sorbitan sesquioleate used pharmaceutically contains in the fatty acid fraction 65.0 to 88.0% oleic acid, also linoleic acid (maximum 18.0%), palmitic acid (maximum 16.0%), palmitoleic acid (maximum 8.0%), stearic acid (maximum 6, 0%), myristic acid (maximum 5.0%), linolenic acid (maximum 4.0%) and fatty acids with a chain length of more than 18 carbon atoms (maximum 4.0%). Pharmaceutical sorbitan sesquioleate is a pale yellow to pale brownish-yellow paste that turns into a viscous, oily, amber-colored liquid at around 25 ° C. The relative density is about 0.99 and the HLB value is 3.7.

See also

Individual evidence

  1. ↑ Entry on SORBITAN SESQUIOLEATE in the CosIng database of the EU Commission, accessed on April 12, 2020.
  2. ↑ a b EDQM (Ed.): European Pharmacopoeia 8.0 (basic work) . 2014 (Monograph No. 1916). P. 4857 f.
  3. ↑ a b Sorbitan sesquioleate data sheet from Sigma-Aldrich , accessed on April 14, 2020 ( PDF ).
  4. ^ Croda homepage. Retrieved on February 9, 2017 (English, product search for SPAN 83).
  5. ↑ Sorbitan Esters (Sorbitan Fatty Acid Esters) . In: Handbook of Pharmaceutical Excipients , 6th edition. RC Rowe, PJ Sheskey, ME Quinn. Pharmaceutical Press, London, 2009. p. 675 ff.