Stephan Grill

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Stephan Grill (2011)

Stephan Wolfgang Grill (born May 5, 1974 in Heidelberg ) is a German biophysicist .

Life

Grill studied physics at the University of Heidelberg and then worked at the European Molecular Biology Laboratory (EMBL) in Heidelberg with Anthony Hyman and Ernst Stelzer, which led to his doctorate on The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo 2002 (official doctorate at the Technical University of Munich ). As a post-doctoral student he was at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden and with Carlos Bustamante at the Lawrence Berkeley National Laboratory (and the University of Berkeley). From 2006 he was a junior research group leader at the MPI for Molecular Cell Biology and Genetics and at the Max Planck Institute for the Physics of Complex Systems in Dresden. In 2009 he was a substitute professor at the University of Leipzig.

Grill has been Professor of Biophysics and Biotechnology at the Technical University of Dresden since 2013. Since September 2018 he has been a Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden.

plant

Grill and his group are studying the role of mechanical processes in cell differentiation ( meiosis , studied in C. elegans - distribution of chromosomes during division via the development of the spindle apparatus and division of cell components via the contraction of a fine network of molecules similar to those in muscles) and you Connection with molecular processes (e.g. given via chemical substance gradients). To this end, he developed a method for demonstrating mechanical stresses in the cell by deliberately cutting through cellular structures with lasers (laser-assisted non-invasive cellular microsurgery). He developed the process at EMBL. In the case of the investigation of cell division, parts of the contractile network of the cell were specifically colored using genetic engineering methods and thus made visible and deliberately severable for the laser. The amount of gaping after severing was a measure of tension.

In Berkeley he started his second research field, the direct observation of molecules during the transcription of DNA into RNA . He was able to follow the movement of the responsible RNA polymerase II on the DNA strand, which not only moves in one direction, but also jumps back and forth. This reflects control processes and correction processes during transcription, which reduce the error rate.

Honors and memberships

In 2010 Grill received the EMBO Young Investigator Award . In 2011 he received the Paul Ehrlich and Ludwig Darmstaedter Prize for young scientists. In 2015, Grill was awarded the Sackler Prize for Biophysics, and in 2017 he was elected to the European Molecular Biology Organization .

Web links

Individual evidence

  1. ↑ Prof. Dr. Stephan Grill. Max Planck Society, accessed on April 20, 2019 .
  2. ↑ BIOTEC: Grill. Accessed October 10, 2018 .
  3. ↑ Laudation by Prof. Dr. Jürgen Bereiter-Hahn. (PDF; 85 kB) University of Frankfurt, accessed on March 15, 2013 .
personal data
SURNAME Grill, Stephan
ALTERNATIVE NAMES Grill, Stephan Wolfgang
BRIEF DESCRIPTION German biophysicist
DATE OF BIRTH May 5th 1974
PLACE OF BIRTH Heidelberg