Synthases
In biochemistry , synthases are enzymes that catalyze the synthesis of a certain substance ; the manufactured substance is explicitly mentioned in the name. Synthases do not have their own EC number assignment.
Since 1984, the nomenclature term synthase has also included enzymes that catalyze a reaction with accompanying hydrolysis of a nucleoside triphosphate (NTP) such as adenosine triphosphate (ATP). ATP-consuming enzymes were previously considered separately and referred to as synthetase . In consideration that not all biochemists distinguish between the meanings of the similar expressions, the recommended names contain the name ligase instead of synthetase . The old synonymsHowever, name forms may still be used by authors who do not share these concerns - even if other NTPs are involved instead of ATP. The occasional notation Synthease can be understood as another synonym for Synthetase .
Examples of synthases are citrate synthase (a transferase ) or argininosuccinate synthase (a ligase). Ligases are classified under EC 6.-.-.- .
Individual evidence
- ↑ JCBN / NC-IUB Newsletter 1984: Synthases and Ligases (English)
- ↑ Entry on Ligase in Flexikon , a Wiki of the DocCheck company