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In biochemistry , synthases are enzymes that catalyze the synthesis of a certain substance ; the manufactured substance is explicitly mentioned in the name. Synthases do not have their own EC number assignment.

Since 1984, the nomenclature term synthase has also included enzymes that catalyze a reaction with accompanying hydrolysis of a nucleoside triphosphate (NTP) such as adenosine triphosphate (ATP). ATP-consuming enzymes were previously considered separately and referred to as synthetase . In consideration that not all biochemists distinguish between the meanings of the similar expressions, the recommended names contain the name ligase instead of synthetase . The old synonymsHowever, name forms may still be used by authors who do not share these concerns - even if other NTPs are involved instead of ATP. The occasional notation Synthease can be understood as another synonym for Synthetase .

Examples of synthases are citrate synthase (a transferase ) or argininosuccinate synthase (a ligase). Ligases are classified under EC  6.-.-.- .

Individual evidence

  1. JCBN / NC-IUB Newsletter 1984: Synthases and Ligases (English)
  2. Entry on Ligase in Flexikon , a Wiki of the DocCheck company