TNF receptor 8
| TNF receptor 8 | ||
|---|---|---|
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| according to PDB 1D01 | ||
| other names |
CD30L receptor, Ki-1 antigen, lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8 |
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| Properties of human protein | ||
| Mass / length primary structure | 595 amino acids , 63,747 Da | |
| Identifier | ||
| External IDs | ||
The TNF receptor 8 (synonymous CD30 ) is a surface protein from the group of TNF receptors .
properties
TNF receptor 8 is the receptor for TNFSF8 (synonymous CD30L ), whereupon NF-κB is formed. It is formed by activated T and B cells and is involved in the activation and cell division of lymphoblasts . It is glycosylated and phosphorylated . TNF receptor 8 is a target in the treatment of Hodgkin lymphoma , e.g. B. by cancer immunotherapy .
TNF receptor 8 binds to TRAF5 , TRAF1 , TRAF2 and TRAF3 .
Web links
Individual evidence
- ^ MA Less, R. Küppers: NF-κB deregulation in Hodgkin lymphoma. In: Seminars in cancer biology. Volume 39, August 2016, pp. 32-39, doi : 10.1016 / j.semcancer.2016.05.001 , PMID 27221964 .
- ^ EC Teo, Y. Chew, C. Phipps: A review of monoclonal antibody therapies in lymphoma. In: Critical reviews in oncology / hematology. Volume 97, January 2016, pp. 72-84, doi : 10.1016 / j.critrevonc.2015.08.014 , PMID 26318093 .
- ↑ a b Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T: Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30 -mediated NFkappaB activation . In: The Journal of Biological Chemistry . 272, No. 4, Jan 1997, pp. 2042-5. doi : 10.1074 / jbc.272.4.2042 . PMID 8999898 .