Lymphotoxin-α
| Lymphotoxin-α | ||
|---|---|---|
|
||
| Ribbon model of the LTA: TNF receptor complex (monomer) according to PDB 1TNR | ||
| Properties of human protein | ||
| Mass / length primary structure | 171 amino acids | |
| Secondary to quaternary structure | Homo- / heterotrimer (3LTA, 2LTA + LTB, LTA + 2LTB) | |
| Identifier | ||
| Gene name | LTA | |
| External IDs | ||
| Occurrence | ||
| Homology family | TNF | |
| Parent taxon | Euteleostomi | |
Lymphotoxin-α ( LTA for short , alternatively also tumor necrosis factor-β , TNFB for short , or, more scientifically, tumor necrosis factor ligand superfamily member 1 , TNFSF1 for short ) is a cytokine from the TNF / TNFR superfamily . It has a lot in common with TNF - shares e.g. B. its receptors - but is secreted by activated lymphocytes . Like TNF, it is an immune response modulator . Mutations in the LTA - gene are with age-related leprosy and psoriatic arthritis associated.
Individual evidence
Web links
- Lymphotoxin-α. In: Online Mendelian Inheritance in Man . (English).
- LTA on KEGG