Lymphotoxin-α
Lymphotoxin-α | ||
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Ribbon model of the LTA: TNF receptor complex (monomer) according to PDB 1TNR | ||
Properties of human protein | ||
Mass / length primary structure | 171 amino acids | |
Secondary to quaternary structure | Homo- / heterotrimer (3LTA, 2LTA + LTB, LTA + 2LTB) | |
Identifier | ||
Gene name | LTA | |
External IDs | ||
Occurrence | ||
Homology family | TNF | |
Parent taxon | Euteleostomi |
Lymphotoxin-α ( LTA for short , alternatively also tumor necrosis factor-β , TNFB for short , or, more scientifically, tumor necrosis factor ligand superfamily member 1 , TNFSF1 for short ) is a cytokine from the TNF / TNFR superfamily . It has a lot in common with TNF - shares e.g. B. its receptors - but is secreted by activated lymphocytes . Like TNF, it is an immune response modulator . Mutations in the LTA - gene are with age-related leprosy and psoriatic arthritis associated.
Individual evidence
Web links
- Lymphotoxin-α. In: Online Mendelian Inheritance in Man . (English).
- LTA on KEGG