Taicatoxin
| Taicatoxin, alpha-neurotoxin-like component | ||
|---|---|---|
| Identifier | ||
| External IDs | ||
| Phospholipase A2 taicatoxin | ||
|---|---|---|
| other names |
Phosphatidylcholine 2-acyl hydrolase |
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| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.1.1.4 | |
| Kunitz-type serine protease inhibitor taicotoxin | ||
|---|---|---|
| other names |
Taicatoxin, serine protease inhibitor component, TCX, TSPI |
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| Mass / length primary structure | 88 amino acids , 9,711 Da | |
| Identifier | ||
| External IDs | ||
Taicatoxin is a toxin from the snake Oxyuranus scutellatus scutellatus (Australian Taipan).
properties
Taicatoxin is a protein complex of three proteins , in a molar ratio of 1: 1: 4: an α- neurotoxin- like peptide of 8 KDa , a phospholipase of 16 KDa and a protease inhibitor of about 7 KDa. Taicatoxin binds and inhibits calcium channels (L-type calcium channels Cav1 / CACNA1 and SK-type) and apamin- sensitive calcium- dependent potassium channels ( KCa2 / KCNN ).
Individual evidence
- ↑ LD Possani, BM Martin, A. Yatani, J. Mochca-Morales, FZ Zamudio, GB Gurrola, AM Brown: Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels. In: Toxicon: official journal of the International Society on Toxinology. Volume 30, Number 11, November 1992, pp. 1343-1364, PMID 1485334 .
- ↑ KB Doorty, S. Bevan, JD Wadsworth, PN Strong: A novel small conductance Ca2 + -activated K + channel blocker from Oxyuranus scutellatus taipan venom. Re-evaluation of taicatoxin as a selective Ca2 + channel probe. In: The Journal of biological chemistry. Volume 272, Number 32, August 1997, pp. 19925-19930, PMID 9242659 .