Takao Shimizu (biochemist)

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Takao Shimizu ( Japanese 清水 孝 雄 , Shimizu Takao ; born April 26, 1947 in Tokyo Prefecture ) is a Japanese biochemist .

Life

In 1968 Shimizu graduated from the University of Tokyo with a degree in Liberal Arts . At the same university he studied medicine , which he completed in 1973 with an MD . Until 1975 Shimizu worked as an intern in internal medicine at Tokyo University Hospital before he went to the Department of Biochemistry at Kyoto University as a research assistant . In 1977 he got a position as Assistant Professor of Medicinal Chemistry at Hayaishi Osamu and in 1980 earned a Ph.D. with his thesis Metabolism and function of prostaglandin D in the brain and blood platelets. in medical sciences. From 1982 to 1984 Shimizu worked as a visiting researcher with Bengt Samuelsson at the Karolinska Institutet near Stockholm

In 1984 Shimizu became Associate Professor of Biochemistry and Nutrition at the University of Tokyo , and in 1991 he was given a full professorship in Biochemistry. From 2003 Shimizu was vice dean of the local medical faculty, since 2007 he has been dean .

Shimizu is married and has two children.

Act

Shimizu's work is primarily concerned with the metabolism of phosphoglycerides and that of lipids with a messenger function (lipid mediators) , in particular eicosanoids , including prostaglandins and leukotrienes . He succeeded in isolating numerous enzymes that are involved in the dynamic remodeling of biomembranes or the synthesis of lipid messenger substances, and he cloned G-protein-coupled receptors for lipid messengers. Shimizu developed a method of liquid chromatography with mass spectrometry coupling for the quantification of a large number of lipid messenger substances and membrane phospholipids . His research focuses on the question of what differences in the structure and function of biological membranes are caused by lipid messengers.

Awards (selection)

Web links

Individual evidence

  1. Ernst Schering Prize 2000 from the Schering Foundation
  2. Japan Academy Prize to Takao Shimizu (PDF)