Thermolabile hemolysin
| Thermolabile hemolysin | ||
|---|---|---|
| other names |
Atypical phospholipase, lecithin-dependent hemolysin, LDH, TLH |
|
| Mass / length primary structure | 418 amino acids , 47,392 Da | |
| Identifier | ||
| External IDs | ||
Thermolabils hemolysin is a protein from various Vibrio parahaemolyticus and a microbial exotoxin .
properties
The thermolabile hemolysin (TLH) is a hemolysin . In V. parahaemolyticus , the thermostable direct hemolysin (TDH) is also formed. It is a phospholipase that can hydrolyze both fatty acid groups of phospholipids , e.g. B. Phosphatidylcholine (PC) to Lysophosphatidylcholine (LPC) and then on to Glycerophosphorylcholine (GPC). This partially disintegrates the cell membrane .
literature
- CK Gutierrez West, SL Klein, CR Lovell: High frequency of virulence factor genes tdh, trh, and tlh in Vibrio parahaemolyticus strains isolated from a pristine estuary. In: Applied and environmental microbiology. Volume 79, number 7, April 2013, pp. 2247-2252, doi : 10.1128 / AEM.03792-12 , PMID 23354697 , PMC 3623233 (free full text).
Web links
Individual evidence
- ↑ H. Taniguchi, H. Hirano, S. Kubomura, K. Higashi, Y. Mizuguchi: Comparison of the nucleotide sequences of the genes for the thermostable direct hemolysin and the thermolabile hemolysin from Vibrio parahaemolyticus. In: Microbial pathogenesis. Volume 1, Number 5, October 1986, pp. 425-432, PMID 3508495 .